帕利哌酮缓释片治疗精神分裂症的疗效与安全性  

Efficacy and Safety of Paliperidone Extended-release Tablets in the Treatment of Schizophrenia

作　　者：杨铭哲[1] 林昭宇[1] 梁云海[1] 吴逢春[1] 蒲绮霞[1] 蓝晓嫦[1] 

机构地区：[1]中国.广州市精神病医院,510370

出　　处：《中国健康心理学杂志》2013年第5期646-648,共3页China Journal of Health Psychology

摘　　要：目的探讨帕利哌酮缓释片治疗精神分裂症的疗效和安全性。方法对60例急性住院精神分裂症患者,予口服帕利哌酮缓释片一天一次给药,可根据患者病情调整剂量,为期8周。采用阳性和阴性症状量表(PANSS)评价精神症状变化,个人和社会功能量表(PSP)评价社会功能情况,临床疗效总评量表(CGI-s)评定总体病情,不良反应症状量表(TESS)评估不良反应,分别于治疗前及治疗第1、2、4、8周末进行评估。实验设计为单臂,以自身为对照。结果经口服帕利哌酮缓释片治疗后,研究对象的PANSS总分较治疗前明显下降,差异有统计学意义(t=701.545,P=0.000),PSP分值较治疗前明显提高,差异有统计学意义(t=42.608,P=0.000),CGI-s分值较治疗前明显下降,差异有统计学意义(t=17.869,P=0.000)。未出现严重不良反应,30%病人出现椎体外系不良反应(EPS),大多为轻度。结论帕利哌酮缓释片可有效改善精神分裂症的症状,提高个人和社会功能,并具有良好的耐受性。因此,帕利哌酮缓释片为精神分裂症患者提供一种有效的新的治疗选择。Objective To evaluate the efficacy and safety of paliperidone extended-release （ER）tablets in the treatment of schizophrenia. Methods A total of 60 acute hospitalized patients with schizophrenia were enrolled and received paliperidone ER tablets once daily for 8 weeks,dose adjustments according to the severity of condition. The psychiatric symptoms were assessed with the positive and negative symptoms scale （PANSS）. Social function was assessed with Personal and Social Performance （PSP）,Clini- cal Global Impression Scale （CGI--s）was used to evaluate general disease, side effects were done with the Treatment Emergent Symptom Scale （TESS）. All of the scales were evaluated at the baseline and at the ends of week 1,2,4 and 8 treatment. Results After treatment ,the PANSS total score decreased significantly （t~ 701. 545 ,P~ 0. 000）,the PSP scores was obviously increased （t 42. 608,P~ 0. 000）,CGI--s scores decreased significantly （t~ 17. 869 ,P~ 0. 000）, No serious adverse effects were found. 30~ patients had extrapyramidal side effects during the treatment,mostly modest. Conclusion Paliperidone ER tablets is effective to improve positive symptoms,negative symptoms and social functions of patients with schizophrenia,the patients have a good toler- ance to＂ the drug. paliperidone extended-release（ER）tablets provides a valuable new treatment option for schizophrenia.

关 键 词：帕利哌酮缓释片 精神分裂症 阳性和阴性症状量表 个人和社会功能量表 

分 类 号：R749.3[医药卫生—神经病学与精神病学]