Trapidil对脑梗死患者血小板聚集的影响  

Effect of Trapidil on Platelet Aggregation in Patients with Acute Cerebral Infarction

作　　者：魏丹[1] 李军[1] 

机构地区：[1]武汉市第一医院,武汉430022

出　　处：《中国康复》2000年第3期150-151,共2页Chinese Journal of Rehabilitation

摘　　要：为观察和测定 Trapidil对脑梗死患者血中血小板聚集的影响 ,对 6 1例脑梗死患者采用口服 Trapidil10 0m g/次 ,每日 3次 ,共服用 2周 ,服药前后检查患者血小板聚集率 ,并与对照组 (未服 Trapidil)比较。结果 :脑梗死患者服用 Trapidil2周后 ,5 min血小板聚集率 PAG(5 )和最大血小板聚集率 PAG(m)分别由服药前的平均 74.5 % ,77.0 %下降至 5 5 .0 %和 5 8.2 % ,P <0 .0 1,差异有显著性 ;对照组分别从平均 75 .1% ,77.0 %下降至 6 7.0 %和6 9.3% ,P>0 .0 5 ,差异无显著性。提示 :Trapidil可以降低脑梗死患者血小板的聚集性 ,对防治脑梗死有一定的价值。The effect of trapidil on platelet aggregation in the patients with acute cerebral infarction was investigated. Twenty one patients with cerebral infarction were treated with trapidil for 2 weeks. Tablets trapidil (100 mg/time) were administered three times a day. Before and after treatment, PAG (1), PAG(5) and PAG(m) were measured. It was found that after treatment, the PAG(5) and PAG(m) in the treatment group were decreased from 74 5 % and 77 0 % to 55 0 % and 58 2 % respectively ( P <0 01), while the PAG(5) and PAG(m) in the control group were declined from 75 1 % and 77 % to 67 0 % and 69 3 % respectively ( P >0 05). It was concluded that trapidil could significantly inhibit platelet aggregation in the patients with acute cerebral infarction, which was valuable of prevention and treatment of cerebral infarction.

关 键 词：血小板聚集 脑梗死 ADP TRAPIDIL 药物疗法 

分 类 号：R743.33[医药卫生—神经病学与精神病学]