泌尿道肾源性腺瘤2例报告及文献复习  

Nephreogenic adenoma in urinary tract: a report of 2 cases and review of literature

作　　者：沈无名[1,2] 周军[1] 夏春[1] 张新华[1] 石群立[1] 

机构地区：[1]南京大学医学院临床学院/南京军区南京总医院病理科,210002 [2]常州市儿童医院病理科

出　　处：《中国临床研究》2013年第5期437-439,F0002,共4页Chinese Journal of Clinical Research

摘　　要：目的探讨泌尿道肾源性腺瘤的临床病理特征、诊断与鉴别诊断。方法对2例泌尿道肾源性腺瘤的临床、组织学及免疫组织化学特点进行分析,结合相关文献讨论。结果 2例患者年龄分别为27岁和48岁,男、女各1例,病变部位分别位于膀胱和肾盂。临床缺乏特异性症状,主要表现为血尿或尿路刺激症状。组织学上肿瘤呈腺样、管状或乳头状结构,被覆立方或柱状上皮,异型性不明显;免疫组织化学(EnVision法)瘤细胞示CKpan、CK7、Pax-2、CD10、Vim均阳性,P63局灶阳性,CK5/6、PSA、P504S均阴性,Ki67呈低表达。结论肾源性腺瘤是发生在泌尿道少见的良性肿瘤,它的正确诊断需要结合病理形态及免疫组化指标,并与相关疾病鉴别。Objective To investigate the clinicopathologic characteristics,diagnosis and differential diagno-sis of nephrogenic adenoma （NA） in urinary tract. Methods Combined with review of the literature, the clinical, histological, and immunohistochemieal characteristics of 2 cases of NA were analyzed. Results The 2 cases of NA were comprised of 1 male and 1 female,with age 27and 48 respectively, and anatomic locations including bladder and renal pelvis. Both of them lacked of specific clinical manifestations, and mainly represented hematuria or urinary irri- tation. Histologically, the tumor consist of gland-like, tubular, or papillary stracture lined by cuboidal or columnar epi-theium without obvious atypia. Immunochemistrically （EnVision） ,tumor cells were positive for CKpan, CK7, Pax-2, CD10, Vim, partly positive for P63 and negative for CK5/6, PSA, P504S, while low expression of Ki-67. Conclusion NA is a rare benign tumor in urinary tract. A correct diagnosis need to combine morphology and immunohistochem-istry, and exclude other the relevant disease of urinary tract.

关 键 词：肾源性腺瘤 泌尿道 病理诊断 

分 类 号：R737[医药卫生—肿瘤]