脑胶质瘤P^(16)蛋白表达与肿瘤细胞增殖活性关系的研究  

Study on the relationship between p^(16) protein expression and the proliferation activity of tumor cells of brain glioma

作　　者：曲春城[1] 张延庆[1] 李雪燕[1] 梁兵[1] 杨峰[2] 孙保存[3] 余虹[3] 

机构地区：[1]济宁医学院附属医院,山东济宁272129 [2]金乡县人民医院 [3]天津医科大学

出　　处：《山东医药》2000年第16期6-8,共3页Shandong Medical Journal

基　　金：山东省教委课题! ( NO:J98K69)

摘　　要：检测 41例不同级别脑胶质瘤标本和 7例正常脑组织 P1 6 蛋白表达情况和 PCNA指数。结果 :实验组P1 6蛋白表达缺失 2 7例 ,占 6 5 .85 %。P1 6蛋白表达缺失率和 PCNA指数随脑胶质瘤恶性程度级别增高呈上升趋势(P<0 .0 5 )。 PCNA指数与 P1 6 蛋白表达具有明显相关性 (P<0 .0 1)。表明 P1 6To study the relationship between P 16 protein expression and the malignant grades of brain glioma and the proliferation activity of tumor cells,the P 16 and PCNA protein expression were detected in 41 brain glioma specimen with different grades and 7 normal brain tissue specimen The results showed in the experimental group,the deletion of P 16 protein expression were found in 65 9%(27/41)cases The deletion of P 16 protein ex[KG(-30]pression and increase of PCNA index were related to the increase of malignant grade of brain glioma significantly(P<0 05) Also the P 16 protein expression was related to the change of PCNA index dominantly(P<0 01) We conclude the abnormity of cell cycle modulation and increase of cellular proliferation activity are caused by deletion and mutation of P 16 gene is an important factor to influence the biological characteristics of brain glioma

关 键 词：PCNA 脑胶质瘤 P16蛋白 细胞增殖 

分 类 号：R739.410.2[医药卫生—肿瘤]