模拟生物膜上识别桑色素药物效能的机理研究  

Research on the Drug Efficacy of Morin in Mimetic Membrane

作　　者：廖天录[1] 廖天江[1] 

机构地区：[1]甘肃工业职业技术学院化工学院,甘肃天水741025

出　　处：《广东化工》2013年第9期59-61,共3页Guangdong Chemical Industry

基　　金：甘肃工业职业技术学院科研基金资助项目(Gzy2011-17)

摘　　要：以玻碳电极支撑的磷脂双层膜(s-BLM)作为生物膜的模型,Fe(CN)63-/4-为探针分子,利用循环伏安(CV)、交流阻抗法(EIS)和扫描电化学显微镜(SECM)技术研究了桑色素与s-BLM的相互作用,结果表明桑色素与s-BLM之间可以发生强烈的相互作用,引起s-BLM表面分子的排列变化,进而在膜的表面形成不可逆的微孔,而探针分子Fe(CN)63-/4-可以通过微孔接近电极,产生氧化还原响应。The supported bilayer lipid membrane（s-BLM） was served as a biomembrane model and Fe（CN）63 /4 as the probe ion.The interaction between morin and s-BLM was investigated by means of cyclic voltammetry and impedance spectroscopy（EIS） and scanning electrochemical microscope（SECM）.The results show that that the interaction between morin and lipid membranes leaded Fe（CN）63-/4-to cross the s-BLM.This phenomenon suggested that some kinds of pores form on the surface of membrane which decreased membrane resistibility to the probing molecules and resulted in the interaction between morin and lipid membranes.

关 键 词：桑色素 循环伏安法 交流阻抗 支撑磷脂双层膜 扫描电化学显微镜 

分 类 号：O614.31[理学—无机化学]