MDM2–309 T>G基因多态性与东亚人群胃癌风险关系的Meta分析  

MDM2–309 T>G Gene Polymorphism and Gastric Cancer Risk in Eastern Asian Population:A Meta-Analysis

作　　者：冉恒泉[1] 周勇[1] 陈博[1] 杨平[1] 伍晓汀[1] 

机构地区：[1]四川大学华西医院胃肠外科,成都610041

出　　处：《中国循证医学杂志》2013年第5期560-563,共4页Chinese Journal of Evidence-based Medicine

基　　金：国家自然科学基金:泛素-蛋白酶体降解途径介导胃肠道间质瘤的靶向调控及作用机制(编号:81172374)

摘　　要：目的探讨东亚人群中MDM2 SNP309与胃癌风险的关系。方法计算机检索MEDLINE、EMbase和CBM数据库,检索时限均为1990.1.1至2012.12.23,搜集研究东亚人群中MDM2 SNP309与胃癌风险的病例-对照研究。由两位研究者独立进行文献筛选、资料提取和纳入研究的方法学质量评价后,采用RevMan 5.0软件进行Meta分析。结果共纳入5个病例-对照研究,包括1 621例胃癌患者,2 639例对照。Meta分析结果显示:与野生型纯合子(309TT)基因型个体相比,变异纯合子(309GG)基因型个体与胃癌风险增高相关[OR=1.54,95%CI(1.04,2.29),P=0.02],然而杂合子(309TG)基因型个体与胃癌风险增高相关性无统计学意义[OR=1.03,95%CI(0.75,1.42),P=0.006]。在隐形遗传模式中(GG vs.TG/TT)胃癌风险增高且有统计学意义[OR=1.49,95%CI(1.20,1.84),P=0.07],但在显性遗传模式中(GG/TG vs.TT)这种风险增高无统计学意义[OR=1.18,95%CI(0.84,1.65),P=0.001]。结论在东亚人群中,MDM2 309GG基因型个体可能存在较高的胃癌风险。Objective To investigate the correlation between MDM2 SNP309 and gastric cancer （GC） risk in Eastern Asian population. Methods Two reviewers independently searched MEDLINE, EMbase and CBM （from January 1st, 1990 to October 23rd, 2012） for case-control studies on the correlation between MDM2 SNP309 and GC risk in Eastern Asian population. Two reviewers independently screen literature, extracted the data, and assessed the methodological quality. ＂/hen meta-analysis was performed using RevMan 5.0 software. Results 5 case-control studies were finally included involving 1 621 GC cases and 2 639 controls. The pooled results showed that the variant homozygote （309GG genotype） was significantly associated with an increased risk of GC as compared to wild-type homozygote （309TT genotype： OR=1.54, 95% CI 1.04 to 2.29, P=0.02）. Nevertheless, no association was found in comparison of variant heterozygote （309TG genotype） between wild- homozygote （309TT genotype： OR= 1.03, 95% CI 0.75 to 1.42, P=0.006）. A significantly increased risk of GC was observed for the recessive model （GG vs. TT/TG： OR=1.49, 95% CI 1.20 to 1.84, P=0.07）. While in the dominant model （GG/TG vs. TT）, non-significant association was observed （OR=1.18, 95% CI 0.84 to 1.65, P=0.001）. ConcLusion The MDM2 309GG may be significantly associated with an increased risk of GC among Eastern Asians.

关 键 词：胃癌 鼠双微体基因2(MDM2) 单核苷酸多态性(SNP) META分析 病例-对照研究 

分 类 号：R735.2[医药卫生—肿瘤]