miR-128与恶性肿瘤关系的研究进展  

Research progress on the relationship between miR-128 and malignant tumors

作　　者：李墨林[1] 沃璐璐[2] 付红勇[1] 方龙[1] 李传刚[3] 舒晓宏[4] 

机构地区：[1]大连医科大学病理生理学教研室,大连116044 [2]大连医科大学医疗系,2010级大连116044 [3]大连医科大学附属二院泌尿外科,大连116023 [4]大连医科大学药学院,大连116044

出　　处：《生命科学》2013年第5期484-489,共6页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(81072063);大连市科技计划项目(2012E15SF159)

摘　　要：微小RNA（microRNA，miRNA）是一类长度为19～25个核苷酸、细胞内源性表达的单链非编码RNA，其通过转录后抑制或mRNA降解调控靶基因的表达，进一步调控靶蛋白参与的信号通路。微小RNA－128（miR－128）是一种在神经系统中高表达的miRNA，在神经系统的发育及正常生理功能的维持中发挥重要作用，其异常表达与神经胶质瘤、阿尔茨海默病等疾病密切相关。近年研究证实，miR－128与多种肿瘤细胞的增殖、分化、凋亡、侵袭和转移有关。miR－128已成为与肿瘤诊断、治疗和预后相关的具有潜在价值的肿瘤标志物，并有望成为肿瘤治疗的新靶点。就miR-128与恶性肿瘤关系的研究进展进行综述。MicroRNAs （miRNAs） are a class of small endogenous non-coding single chain RNAs containing 19-25 nucleotides, which regulate the expression of target genes through post-translational repression or mRNA degradation, thus further modulating its related signal transduction networks. MicroRNA-128 （miR-128） is a kind of brain-enriched miRNA, and plays important roles in the development of the nervous system and the maintenance of its normal physiological functions. It was reported that the aberrant expression of miR-128 is closely associated with glioma, Alzheimer＇s disease, etc. Recent studies demonstrated that miR-128 is involved in proliferation, differentiation, apoptosis, invasion and metastasis of various tumor cells, miR-128 may serve as potential biomarkers for cancer diagnosis, treatment and prognosis, and is expected to become a new target for tumor therapy. In this review, we will focus on the relationship between miR-128 and malignant tumors.

关 键 词：miR-128 恶性肿瘤 靶基因 

分 类 号：Q74[生物学—分子生物学] R730[医药卫生—肿瘤]