胰腺癌3DCRT联合化疗的疗效分析  被引量:1

Effect of three-dimensional conformal radiation therapy(3DCRT) combined with chemo-therapy to cancer of pancreas

在线阅读下载全文

作  者:胡建新[1] 古伟光[1] 贺志仁[1] 罗海涛[1] 徐敏[1] 

机构地区:[1]南方医科大学附属南海医院肿瘤科,广东佛山528200

出  处:《现代肿瘤医学》2013年第5期1084-1086,共3页Journal of Modern Oncology

摘  要:目的:观察三维适形放射治疗(3 dimensional conformal radiotherapy,3DCRT)联合化疗治疗胰腺癌的临床疗效。方法:回顾分析我院自2006年1月至2011年6月收治的60例胰腺癌患者。治疗组28例,于化疗第1天行3DCRT,每周期第1、8、21、29天静滴吉西他滨(GEM)1000mg/m2,草酸铂130mg/m2,静脉滴注。对照组32例,给予每周期第1、8、21、29天静滴GEM 1 000mg/m2,草酸铂130mg/m2,静脉滴注。比较两组治疗完成情况、临床疗效、毒副反应及生存情况。结果:治疗组治疗完成率89.29%,对照组治疗完成率93.75%,两组在统计学上差异无显著性意义(P>0.05);两组总有效率分别为25.0%与3.1%(P<0.05)。两组毒副反应主要为血小板减少(28.6%,21.9%),白细胞下降(39.3%,31.3%),胃肠道反应(82.1%,75.0%)以及肝功能变化(10.7%,9.4%),两组毒副反应发生率比较,差异无统计学意义(P>0.05);治疗组与对照组在6个月生存率(82.1%,53.1%)、12个月生存率(46.4%,21.9%)及中位生存期(11.2个月,7.6个月)比较,差异具有统计学显著性意义(P<0.05)。结论:3DCRT+吉西他宾+草酸铂治疗胰腺癌疗效确切,可减轻临床症状。Objective:To study the therapeutic effectiveness of three - dimensional conformal radiation therapy (3DCRT) combined with chemo -therapy to cancer of pancreas. Methods:We analyzed 60 cases with cancer of pancreas from Jan 2006 to June 2011,60 cases were randomly divided into 2 groups:28 cases in the experimental group given 3DCRT,gemcitabine and oxaliplatin,and 32 cases in control group given gemcitabine and oxaliplatin. Results:The completion rate of treatment were no significant statistics differences of 89.29% and 93.75% in 2 groups(P 〉 0.05 ). The total effective rates were significant different of 25.0% and 3.1% ( P 〈 0.05 ). The adverse effect were no significant differences(P 〉 0.05 ), thrombopeny ( 28.6%, 21.9% ), blood corpuscle to fall ( 39.3%, 31.3% ), gastrointestinal react ( 82.1%, 75.0% ), hepatic function ( 10.7%, 9.4% ). There were significant differences of survival rate(P 〈0.05), 6 months survival rate (82.1% ,53.1% ), 12 months survival rate (46.4%, 21.9% ) and median survival( 11.2 months ,7.6 months). Concolusion :3 DCRT + gemcitabine + oxaliplatin were ef- fective for panceatic cancer.

关 键 词:胰腺癌 3DCRT 吉西他宾 草酸铂 

分 类 号:R735.9[医药卫生—肿瘤]

 

参考文献:

正在载入数据...

 

二级参考文献:

正在载入数据...

 

耦合文献:

正在载入数据...

 

引证文献:

正在载入数据...

 

二级引证文献:

正在载入数据...

 

同被引文献:

正在载入数据...

 

相关期刊文献:

正在载入数据...

相关的主题
相关的作者对象
相关的机构对象