Tf-PEG脂质体-rAdp53复合物、rAdp53腹腔内灌注治疗晚期结直肠癌合并恶性腹腔积液的临床研究  

Clinical study of intraperitoneal Tf-PEG-rAdp53 and rAdp53 in advanced colorectal cancer patients with malignant pleural effusion

作　　者：都庆国[1] 张涛[1] 王建华[1] 武敏[1] 杜善平[1] 刘鹏[1] 慕生枝[1] 

机构地区：[1]陕西省人民医院普外二科,陕西西安710068

出　　处：《现代肿瘤医学》2013年第5期1087-1090,共4页Journal of Modern Oncology

基　　金：陕西省自然科学基金(编号:2011JM4028)

摘　　要：目的:观察Tf-PEG脂质体-rAdp53复合物、rAdp53腹腔内灌注治疗晚期结直肠癌合并恶性腹腔积液临床疗效。方法:采用Tf-PEG脂质体-rAdp53复合物、rAdp53治疗晚期结直肠癌合并恶性腹腔积液患者,随机分为3组,每组22例。观察组:制备Tf-PEG脂质体-rAdp53复合物,溶于20ml生理盐水后注入腹腔,再缓慢灌入40℃的灭菌用水1000ml+地塞米松10mg。对照组:将1支rAdp53(1×1012VP)+灭菌用水1000ml+地塞米松10mg混合后腹腔灌注。空白组:灭菌用水1000ml+地塞米松10mg腹腔灌注。4周后评价其疗效及不良反应。结果:观察组总有效率90.90%(20/22);对照组总有效率72.73%(16/22);空白组总有效率22.72%(5/22)。观察组和对照组有效率显著高于空白组,且观察组有效率亦显著高于对照组(P<0.05)。观察组和对照组中获RR患者Karnofsky评分较治疗前明显提高且腹围减小。结论:Tf-PEG脂质体-rAdp53复合物较rAdp53在腹腔灌注治疗晚期结直肠癌合并恶性腹腔积液的疗效更明显,不良反应较小。Objective：To investigate the efficiency of intraperitoneal perfusing Tf - PEG - recombinant adenoviral p53 （rAdp53） , rAdp53 to treat malignant peritoneal effusion in advanced colorectal cancer. Methods：We evaluated the efficiency of intraperitoneal perfusing Tf - PEG - rAdp53, rAdp53 to treat malignant peritoneal effusion in advanced colorectal cancer. The patients were divided into three groups randomly,22 patients per group. In observation group： intraperitoneal perfused Tf- PEG - rAdp53 dissolved in 20ml normal saline, then perfused 40℃ sterilization water 1000ml and dexamethasone 10mg;Control group：intraperitoneal perfused the mixture of 10nVP rAdp53, sterilization water 1000ml and dexamethasone 10mg; Blank group： intraperitoneal perfused sterilization water 1000m] and dexamethasone 10mg. Results： The total effective rate was 90.90% （ 20/22 ） in observation group,72.73 % （ 16/22 ） in control group and 22.72% （5/22）in blank group. The effective rates of observation group and control group were remarkable higher than that of blank group. The effective rate of observation group was remarkable higher than that of control group （ P 〈 0.05 ）. In observation group and control group, Karnofsky score of RR patients was higher and abdominal circumference become lower than pretreatment. Conclusion： Intraperitoneal perfusion of Tf- PEG- rAdp53 to treat malignant peritoneal effusion in advanced colorectal cancer is more effective than intraperitoneal perfusion of rAdp53.

关 键 词：恶性腹腔积液 重组人P53腺病毒注射液 转铁蛋白 

分 类 号：R735.3[医药卫生—肿瘤]