叶酸受体介导靶向药物载体的研究进展  

Research progress in targeting drug carriers mediated by Folate receptor

作　　者：郭林峰[1,2] 蒋宗林[2] 李东红[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所二室,创伤,烧伤,复合伤国家重点实验室,重庆400042 [2]西华师范大学化学系,四川南充637002

出　　处：《现代肿瘤医学》2013年第5期1128-1131,共4页Journal of Modern Oncology

基　　金：国家自然科学基金资助项目(编号:21072227)

摘　　要：利用叶酸受体在肿瘤细胞(高表达)和正常细胞(低表达)上表达的差异性及叶酸受体与叶酸和叶酸类似物结合的高特异性、高亲和性,可望实现肿瘤的靶向性治疗。而叶酸修饰的药物载体不仅可实现难溶或不稳定药物的体内输送,减少体内酶对药物的降解,提高其生物利用率,同时还可有效地提高药物在肿瘤组织中的浓度,降低对正常组织的毒副作用。本文就近年来叶酸化药物载体的研究进展做一简要综述,旨在为肿瘤的靶向性治疗提供参考。The targeted therapy for tumor is expected to be achieved due to the expressive diversity of Folate receptor on tumor cells （high express） and on normal cells （low express）, and due to the high specific and high affinity conjunction of folate receptor with folio acid and folic acid analogues. Drug carriers modified by folic acid not only can convey the indissolvable or unstable drugs in vivo but also raise the drug concentration in tumor tissues and decrease the side effect on normal tissue. This paper makes a brief review on the research progress of targeting drug carriers modified by folic acid during the past few years so that offer some references for the research of targeted therapy of tumors.

关 键 词：叶酸 叶酸受体 纳米粒子 脂质体 树状大分子 

分 类 号：R730.5[医药卫生—肿瘤]