鱼的摄入与肾癌发病风险关系的Meta分析  

A meta-analysis of fish intake and the risk of renal cell cancer

作　　者：万沛[1] 李妍[2] 李飞[1] 马天骏[2] 蓝开健[1] 陈炜[1] 陈三三[1] 何成武[1] 谭万龙[1] 

机构地区：[1]南方医科大学南方医院泌尿外科 [2]南方医科大学临床医学八年制,广东广州510515

出　　处：《南方医科大学学报》2013年第5期772-775,共4页Journal of Southern Medical University

基　　金：广东省自然科学基金(S2011010003912)

摘　　要：目的应用meta分析的方法对各项研究进行系统分析以研究鱼的摄入与肾癌发病风险关系。方法在PubMed,Embase,CNKI,CA中检索有关鱼及其产品的摄入与肾癌关系的病例对照研究以及队列研究的文献。通过meta分析方法研究鱼的摄入与肾癌的关系。运用I^2检验各项研究的异质性,并使用漏斗图检验发表偏倚。结果共纳入17篇文献,采用随机效应模型合并分析后的结果未发现鱼的摄入与肾癌的发病风险相关(RR=0.90;95%CI,0.78～1.02)且异质性明显(P=0.003,I^2=52.3%),针对研究类型、研究地区以及发表时间进行亚组分析,同样没有明显的证据证明两者相关,但在性别亚组的分析中发现,男性增加鱼的摄入可降低肾癌的发病率,而在女性中则没有关系。结论 meta分析结果提示增加鱼的摄入未发现有预防肾癌发病的作用。Objective To explore the association of fish intake with the risk of renal cancer. Methods PubMed, Embase, CNKI and CA databases were searched for case-control studies or cohort studies examining the relationship between fish or fish products intake and renal cancer. Heterogeneity among the selected studies was assessed using 12 score, and the publication bias was assessed using funnel plots. Results Seventeen articles were included in the analysis with a heterogeneity across the studies （P=0.003, I2=52.3% ）. A random-effects model was used to generate the pooled risk ratio （RR） and 95% confidence interval （CI）, and no statistically significant association was found between the risk of renal cancer and fish intake （RR=0.90; 95% CI, 0.78-1.02）. In subgroup analysis, no evidence was found that the study design, study region or publication date influenced the results; but in the gender subgroup analysis, fish intake we found to decrease the risk of renal cancer in men but not in women. Conclusion The results of meta-analysis do not support an association between fish intake and a lowered risk of renal cancer.

关 键 词：肾癌 鱼 META分析 

分 类 号：R737.11[医药卫生—肿瘤]