伤科熏洗方对佐剂性关节炎大鼠血清炎症因子的调节作用  

Regulating Effects of Shangke Xunxi Formula on Serum Inflammatory Factors in Adjuvant Arthritis Rats

作　　者：熊鹏程[1] 沈霖[1] 卢芙蓉[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院中西医结合科,武汉430022

出　　处：《中国中医骨伤科杂志》2013年第5期1-3,共3页Chinese Journal of Traditional Medical Traumatology & Orthopedics

基　　金：国家自然科学基金(NO:81001670)

摘　　要：目的:探讨伤科熏洗方对佐剂性关节炎(AA)大鼠血清肿瘤坏死因子-α(TNF-α)和白介素-1β(IL-1β)的调节作用。方法:30只Wistar大鼠随机分为对照组、模型组和治疗组,每组10只。模型组和治疗组采用完全弗氏佐剂构建佐剂性关节炎大鼠模型,治疗组采用伤科熏洗方外用熏洗治疗。观察AA大鼠足趾肿胀、关节炎指数、病理改变以及血清TNF-α和IL-1β的变化。结果:与对照组相比,AA大鼠足趾明显肿胀,炎症指数增高,病理改变明显,血清TNF-α和IL-1β水平显著升高;经伤科熏洗方治疗后,足趾肿胀明显消退,炎症指数降低,病理改变减轻,血清TNF-α和IL-1β水平明显下降(P<0.05)。结论:伤科熏洗方可能通过抑制炎症因子TNF-α和IL-1β的表达,达到治疗大鼠佐剂性关节炎的作用。Objective：To investigate the effect of Shangke Xunxi Formula （SXF） on serum tumor necrosis factor-α （TNF-α） and interleukin-1β （IL-1β） in adjuvant arthritis （AA） rats. Methods： Thirty Wistar rats were randomly divided into control group, model group and treatment group, 10 rats in each group. Complete Freund＇s adjuvant （CFA） was used to establish AA models in model group and treatment group. Rats in treatment group received fumigation with SXF. Swelling degree of toes, arthritis index （AI）, pathology change, serum TNF-α and IL-1β were detected in the treatment progress. Results： Compared with control group, swelled toes, increased AI, obvious pathological lesion, increased serum TNF-α and IL-1β were observed in model group. However, after fuming-washing therapy with SXF,toes swelling degree, AI, pathological lesion, serum TNF-α and IL-1β were decreased significantly （P〈0.05） in treatment group. Conclusion..SXF might be effec- tive to AA via inhibiting the expressions of inflammatory factor TNF-α and IL-1β.

关 键 词：伤科熏洗方 佐剂性关节炎 肿瘤坏死因子-Α 白介素-1Β 

分 类 号：R-33[医药卫生]