Proteasome-independent p53 degradation  

作　　者：Mais M Nuaaman Samuel Benchimol 

机构地区：[1]Department of Biology, York University, To-ronto, ON M3J 1P3, Canada

出　　处：《Cell Research》2013年第5期597-598,共2页细胞研究（英文版）

摘　　要：The intracellular levels of the p53 tumor suppressor protein are regulated through various pathways and involve numerous regulatory components. A recent study published in CellResearch identifies a proteasomeindependent pathway of p53 protein degradation in the nucleolus that is dependent on Def and Calpain3.

关 键 词：P53蛋白 降解途径 蛋白酶体 抑制蛋白 细胞内 元器件 DEF 肿瘤 

分 类 号：Q71[生物学—分子生物学] X172[环境科学与工程—环境科学]