ERCC1基因多态性与非小细胞肺癌预后的相关性  

Relationships between polymorphisms of ERCC1 and efficacy of non-small cell lung cancer receiving radiation therapy

作　　者：王伟力[1] 潘宏[1] 钟文[1] 郭根燕[1] 周春宇[1] 张国云[1] 

机构地区：[1]中国医科大学附属第四医院肿瘤放射治疗科,辽宁沈阳110032

出　　处：《中国实验诊断学》2013年第5期854-857,共4页Chinese Journal of Laboratory Diagnosis

摘　　要：目的研究证实ERCC1基因多态性与非小细胞肺癌预后的相关性。方法对119例接受胸部根治性放疗的非小细胞肺癌患者进行ERCC1基因分型,统计分析其与患者放疗后总生存的相关性。结果 Codon118基因型频率分别为TT45.4%(54/119)、TC39.5%(47/119)、CC15.1%(18/119)。C8092A基因型频率分别为CC48.7%(58/119)、CA39.5%(47/119)、AA11.8%(14/119)。Condon118的TT基因型与CT/CC基因型患者总生存的差异具有统计学意义(59.3%vs75.4%,P=0.034)。而C8092A的CC基因型与CA/AA基因型患者总生存的差异无统计学意义(62.1%vs78.7%,P=0.052)。结论 ERCC1Codon118多态性可能与非小细胞肺癌患者预后相关联。Objective To explore the relationships between polymorphisms of ERCC1 and the efficacy of radiation therapy in non-small cell lung cancer patients. Methods 119 non-small cell lung cancer patients treated with definitive radiation therapy were enrolled in this study. The ERCC1 genotypes were determined by RFLP-PCR method. Survival analysis was performed to evaluate the relationship between OS and ERCC1 genotypes. Results The frequency of Codon118 was TT45.4% （54/119） ,TC39. 5% （47/119） ,CC15. 1% （18/119）,and the frequency of C8092A was CC48.70%（58/119） ,CA39.5%（47/119） ,AA11. 8% （14/119）. The survival difference between TT genotype and CT/CC genotype of Codonll8 was statistically significant but not C8092A. Conclusion The polymorphisms of ERCC1 Codonll8 may be significantly associated with radiation therapy efficacy.

关 键 词：基因多态性 ERCC1基因 非小细胞肺癌 放射治疗 预后 

分 类 号：R734.2[医药卫生—肿瘤]