Ki67、Her-2在Luminal型乳腺癌中表达的相关性研究  

Correlation of Her-2 and Ki67 expression in the luminal breast cancer

作　　者：沈三弟[1] 陈卓荣[1] 肖高芳[2] 黄湛[1] 

机构地区：[1]广东省粤北人民医院头颈乳腺外科,广东韶关512026 [2]广东省粤北人民医院病理科,广东韶关512026

出　　处：《重庆医学》2013年第16期1820-1821,1823,共3页Chongqing medicine

基　　金：韶关市科技计划项目(2012CX/K72)

摘　　要：目的探讨Ki67与Her-2在Luminal型乳腺癌组织中的表达的相关性及与病理分级之间的关系。方法采用免疫组织化学法(IHC)检测221例甲醛固定的乳腺癌组织标本中Ki67和Her-2的表达强度以及组织病理学分级,用Spearman秩相关分析Ki67、Her-2的表达强度以及组织病理学分级的相关性。结果 Ki67与Her-2的表达强度呈中度正相关(r=0.605,P<0.01),Her-2的表达强度与组织病理学分级呈中度正相关(r=0.455,P<0.01),Ki67的表达强度与病理分级呈正相关(r=0.489,P<0.01)。结论在Luminal型乳腺癌组织中,Ki67、Her-2的表达强度、组织病理分级之间呈正相关,用IHC检测Ki67的表达及病理分级对Her-2阳性判断具有参考价值。Objective To investigate the correlation among Ki67. Her-2 expression intensity and the pathological grade in the Luminal breast cancer tissue. Methods The Ki67, Her-2 expression intensity and histopathological grade were detected by immuno-histochemistry（IHC） in 221 cases of formalin-fixed breast cancer tissue specimens. The correlation of Ki67, Her-2 expression inten sity,and histopathologic grade were analyzed by the Spearman rank correlation. Results The expression intensity of Ki67 was mod- erate positive correlative with that of Her-2（r=0. 605 ,P〈0.01） ,the expression intensity of Her-2 showed a moderate positive cor-relative with histopathologic grade（r=0. 455, P%0.01）. The expression intensity of Ki67 was positively correlative with the patho- logical grade（r=0. 489,P〈0.01）. Conclusion The expression intensity of the Ki67, Her-2 and histopathological grade are posi-tively correlate in the Luminal breast cancer tissue. The judgment of Her-2 positive can refer to the Ki67 expression and pathological grade detected with IHC.

关 键 词：乳腺肿瘤 KI67 HER-2 病理分级 相关性 

分 类 号：R737.9[医药卫生—肿瘤]