左乙拉西坦与奥卡西平对儿童癫痫的疗效比较  

Efficacy comparision of levetiracetam and oxcarbazepine monotherapy on children epilepsy

作　　者：陈桃[1] 郭渠莲[1] 杨义玲[1] 

机构地区：[1]泸州医学院附属医院儿科,四川泸州646000

出　　处：《重庆医学》2013年第16期1826-1827,共2页Chongqing medicine

摘　　要：目的比较左乙拉西坦(LEX)与奥卡西平(OXC)单药治疗儿童癫痫的疗效及不良反应。方法将103例各种类型癫痫患儿分为A、B组两组,A组55例单用LEX治疗,B组48例单用OXC治疗。观察6个月后进行疗效判定。结果 A组控制率67.27%,总有效率为90.91%,总不良反应率21.82%;B组控制率66.67%,总有效率为89.58%,不良反应率22.92%。两组比较差异无统计学意义(P>0.05)。结论 LEX与OXC单药治疗儿童癫痫均有良好疗效,不良反应较少,可选择作为儿童癫痫一线治疗的药物。Objective To compare the clinical efficacy and adverse reaction of levetiracetam and oxcarbazepine monotherapy in the treatment of children epilepsy. Methods 103 cases of various types of epilepsy patients were divided into A,B group,55 cases in A group with levetiracetam monotherapy,48 cases in group B with oxcarbazepine monotherapy. The therapeutic efficacy were ob-served 6 months later. Results In group A ：the control rate was 67.27%, the total efficiency was 90.91%, the total rate of adverse reactions was 21.82% ;In group B：the control rate was 66.67 %, the total effective rate was 89.58%, the rate of adverse reactions was 22.92%. There was no statistically significant difference between two groups. Conclusion Both levetiracetam monotherapy and oxcarbazepine monotherapy have good curative effect,and less adverse reactions in the treatment of children epilepsy,it can be cho-sen as a first-line drug in treatment of children epilepsy.

关 键 词：左乙拉西坦 奥卡西平 癫痫 治疗结果 儿童 

分 类 号：R742.1[医药卫生—神经病学与精神病学]