不同类型钙化与甲状腺癌的相关性再认识  

Recognition of Sonographically Detected Calcification Patterns and its Relationship with Thyroid Cancinoma

作　　者：郑静[1] 徐金锋[1] 李华峰[1] 罗慧[1] 彭启慧[1] 石秋玲[1] 

机构地区：[1]暨南大学第二临床学院,深圳市人民医院超声科,广东省深圳市518020

出　　处：《中国超声医学杂志》2013年第5期389-391,共3页Chinese Journal of Ultrasound in Medicine

摘　　要：目的探讨甲状腺结节中的钙化类型和微钙化分布特点与甲状腺癌的关系。方法对已行甲状腺手术及穿刺活检的730例患者(764个结节)的病理结果与其术前甲状腺高频超声图像进行回顾性对比研究。结果 764个结节中恶性结节191个,良性结节573个,含钙化结节189个,恶性及良性结节含钙化者分别占55.50%(106/1 91)、14.48%(83/573),P<0.01,含钙化灶与不含钙化的结节恶性构成比分别为56.08%(106/189)、14.78%(85/575),P<0.01;微钙化结节恶性发生率最高(64.39%),粗钙化、周边钙化及含钙化斑的结节亦有恶性的可能(39.13%、28.57%、25.00%)。结论任何形式的钙化都是恶性的风险因素,微钙化更具有特异性,尤其是簇状或密集分布以及合并粗钙化的微钙化结节恶性风险更高。Objective To investigate the relationship of calcification patterns of thyroid nodules with pathological diagnosis of thyroid carcinoma. Methods 730 patients with 764 thyroid nodules undergone thyroidectomy or biopsy were analyzed retrospectively. Results Among 764 thyroid nodules, there were 191 malignant nodules and 573 benign nodules, including 189 calcified nodules. The rates of calcification （55.50%, 106/191） in the malignant group were significantly higher than in the benign group （14.48%, 83/573） （P〈0.01）. The malignant constituent ratio of calci- fied and non-calcified nodules was 56.08% （106/189）and 14.78%（85/575） （P〈0. 01）, respectively. Mierocalcifica tions had the highest incidence （64.39%） of malignancy in all types of calcifications. Coarse calcification, rim calcifi- cation and calcification spot are other features associated with an increased risk of thyroid cancer（39.13 %, 28.57 %, 25.00%, respectively）. Conclusions Any type of sonographically detected calcifications represents a risk of malignan- cy. Microcalcifications have the highest specificity, which greatly incre＇sed the risk of malignancy when microcalcifica tions distribute in cluster and intensively.

关 键 词：甲状腺癌超声 钙化微钙化 

分 类 号：R736.1[医药卫生—肿瘤]