连续和脉冲高强度聚焦超声辐照兔肝VX2移植瘤的比较  

Comparison of Continuous and Pulsed High Intensity Focused Ultrasound Irradiation on Rabbit Liver VX2 Tumor

作　　者：赵欣[1] 邹建中[1] 伍烽[1] 刘芳[1] 李崇雁[1] 

机构地区：[1]重庆医科大学生物医学工程学院,重庆市生物医学工程重点实验室,重庆市超声医学工程中心,省部共建国家重点实验室培育基地,重庆市400016

出　　处：《中国超声医学杂志》2013年第5期456-459,共4页Chinese Journal of Ultrasound in Medicine

基　　金：国家重点基础研究发展计划("973"计划)(No.2011CB707902);国家自然科学基金重点项目(No.30830040);国家自然科学基金面上项目(No.30970827)

摘　　要：目的比较连续和脉冲高强度聚焦超声辐照兔肝VX2移植瘤时的治疗效果。方法将48只荷瘤兔随机分为A、B、C 3组,每组各16只。A组(连续波组)用连续高强度聚焦超声辐照,B、C组(脉冲波组)分别用占空比为75%和50%的脉冲高强度聚焦超声(pulsed high intensity focused ultrasound,PHIFU)辐照。结果 3组消融后的肿瘤组织均发生确切的凝固性坏死,且有效地控制肿瘤复发与转移;与连续波组相比,脉冲波组能效因子(energy efficiency factor,EEF)减小,皮肤红斑发生减少(P<0.05)。结论 PHIFU辐照能达到与连续波辐照相同的治疗效果,实际辐照剂量相当,但损伤效率提高,并发症减少。PHIFU有望成为一种安全、有效的肿瘤治疗方式。Objective To compare continuous and pulsed High Intensity Focused Ultrasound irradiation on rabbit liver VX2 tumor. Methods Totally 48 tumor bearing rabbits were randomly divided into 3 groups,each group con- tained 16 rabbits. Group A（continuous HIFU group） received continuous H1FU irradiation, group B,C （pulse HIFU group） received pulse HIFU irradiation under duty cycle 75% and 50%. Results After irradiation, the exact necrosis in tumor tissues were occurred, and the recurrence and metastasis were controlled in all the three groups. Compared with continuous HIFU group, the total treatment energy of PHIFU group was not significantly different, but the en- ergy efficiency factor（EEF）were less,and the incidence of skin erythemawas lower. Conclusions Pulse irradiation can achieve the same treatment with continuous wave irradiation, Although the actual radiation dose about the same, the damage efficiency increased and the complications were reduced in the pulse HIFU group. Pulsed High Intensity Fo- cused Ultrasound irradiation is a safe and effective treatment of tumor.

关 键 词：脉冲高强度聚焦超声辐照方式损伤效率安全性 

分 类 号：R735.7[医药卫生—肿瘤] R445.1[医药卫生—临床医学]