周围型肺癌病理、CT表现与血清神经元特异性烯醇化酶水平的关系  

Correlation of serum neural specific enolase level with computed tomography and pathology in peripheral lung cancer

作　　者：谭理连[1] 周洁[1] 李志铭[1] 余林[1] 江金带[1] 李树欣[1] 张婉红[1] 

机构地区：[1]广州医学院第二附属医院CT室,510260

出　　处：《中华生物医学工程杂志》2013年第1期60-64,共5页Chinese Journal of Biomedical Engineering

基　　金：基金项目：广州市属高校科技计划项目（61028）;广东省医学科研基金项目（A2004298）

摘　　要：目的探讨周围型肺癌病理、CT表现与血清肿瘤标志物神经元特异性烯醇化酶（NSE）水平的关系。方法回顾性分析2008年1月至2009年8月48例本院经手术病理证实的周围型肺癌患者肺癌病理、CT表现与血清肿瘤标志物NSE资料，对比分析病理、CT表现与血清肿瘤标志物NSE关系。结果腺癌与鳞癌血清NSE浓度差异无统计学意义[（12．11±5．19）比（10．77±4．46）Ixg／L，P=0．098]。肺癌的分化程度与血清NSE浓度无相关（r＝－0．214，P=0．065）。深分叶征及瘤体直径≥3cm肺癌的血清NSE浓度较无深分叶征或瘤体直径〈3 cm高（氏0．05）。肺癌有无胸膜凹陷征、毛刺征、支气管气相，增强值〉／20Hu与〈20Hu、钙化或肺门、纵隔淋巴结有无肿大问血清NSE浓度差异均无统计学意义（P〉0．05）。肺癌Kj－67抗原阳性百分率与血清NSE浓度无相关（r=0．028，P=0．848）。p53表达阴性与p53表达阳性的血清NSE浓度差异无统计学意义[（11．97±5．84）比（11．09±4．52）Ixg／L，P=0．559]。结论肺癌的深分叶征、瘤体直径≥3cm与血清NSE浓度有关联。肺癌的分化程度、Ki-67抗原及p53表达与血清NSE浓度之间无相关。Objective To examine the correlation of the level of serum neural specific enolase（NSE）, a biomarker of tumor, with computed tomography（CT） and pathology in peripheral lung cancer. Methods Clinical profiles of pathology, features of CT and serum NSE in 48 patients with pathology-diagnosed peripheral lung cancer who underwent surgery in The Second Affiliated Hospital of Guangzhou Medical College, between January 2008 and August 2009 were retrospectively analyzed. Their correlation was examined. Results The serum NSE concentration did not differ statistically between patients with adenocarcinoma and squamous carcinoma[ （12.11±5.19） vs （10.77 ±4.46） μg/L, P=0.098]. The serum NSE was not correlated with tumor differentiation （r=-0.214, P=0.065）. Patients with deep lobulation sign and tumor diameter of ~〉3 cm yielded higher level of serum NSE than those without （P〈O.05 ）. There were no marked differences of serum NSE in presence of pleural indentation, spiculation and spinous protuberant sign, increased CT value by ≥20 Hu and 〈20 Hu, calcification or hilar or mediastinal lymph node enlargement（all P〉 0.05）. The positivity of Ki-67 antigen was not correlated significantly with serum NSE（r=0.028, P= 0.848）. Additionally, the difference of serum NSE in patients with and without p53 expression was not statistically significant[（ll.97±5.84） vs （ll.09±4.52）μg/L,P=0.559]. Conclusion Serum NSEis associated with the presence of deep lobulation sign and tumor diameter of ≥3 cm in patients with peripheral lung cancer. There are no correlations of serum NSE with tumor differentiation, p53 and Ki-67 expression.

关 键 词：肺癌 体层摄影术 X线计算机 神经元特异性烯醇化酶 

分 类 号：R734.2[医药卫生—肿瘤]