青年男性血清脂联素与非酒精性脂肪性肝炎的关系  

Relationship between serum adiponectin and non-alcoholic steatohepatitis in young men

作　　者：张璐[1] 张琦[2] 方言[1] 朱奎轩[2] 李珍[1] 

机构地区：[1]清华大学生命科学学院,北京市100084 [2]清华大学医院,北京市100084

出　　处：《世界华人消化杂志》2013年第13期1256-1260,共5页World Chinese Journal of Digestology

摘　　要：目的:探究青年男性非酒精性脂肪性肝炎(non-alcoholic steatohepatitis,NASH)患者血清脂联素总量及脂联素高聚体占总量的比例与NASH的关系.方法:测定64例NASH患者和46例健康患者对照组的转氨酶、血糖、血脂等生化指标及脂联素总量、脂联素各聚体含量,SPSS19.0分析统计.结果:NASH患者血清脂联素总量和高聚体所占比例显著低于正常组,且脂联素总量及高聚体比例随肝炎的严重程度递减.脂联素总量与总胆固醇、低密度脂蛋白负相关;脂联素高聚体比例与体质量指数负相关,与高密度脂蛋白正相关.结论:血清脂联素总量及高聚体占总量比例与青年男性NASH的严重程度密切相关.脂联素总量,尤其是高聚体在总量中所占比例的降低会加重NASH发展程度.AIM：To investigate the relationship between serum adiponectin and non-alcoholic steatohepatitis（NASH） in young men.METHODS：The body mass index（BMI）,alanine aminotransferase,aspartate aminotransferase,total cholesterol（TCHO）,triglyceride,high-density lipoprotein,low-density lipoprotein（LDL）,fasting plasma glucose and fasting plasma insulin were examined in 64 NASH patients and 46 healthy controls.The levels of adiponectin and high molecular weight（HMW） adiponectin were determined by ELISA and Western blot.The data were analyzed using SPSS19.0.RESULTS：The level of total adiponectin and the ratio of HMW to total adiponectin were decreased in men with NASH,compared with controls（total adiponectin：0.92±0.17 vs 1.02±0.16,P0.01;HMW/total：0.39±0.14 vs 0.47 ±0.11,P0.01）.The level of total adiponectin was decreased with the increase in the severity of NASH.Furthermore,the level of total adiponectin inversely correlated with TCHO（r=-0.358,P0.01） and LDL（r=-0.339,P〈0.05）.The ratio of HMW to total adiponectin was inversely correlated with BMI（r=-0.279,P〈0.05）,but positively correlated with HDL（r = 0.266,P〈0.05）.CONCLUSION：The level of total adiponectin and the ratio of HMW to total adiponectin are directly related to NASH in young men.Adiponectin may play an important role in the development of NASH.

关 键 词：非酒精性脂肪性肝炎 脂联素 高聚体 转氨酶 

分 类 号：R575.5[医药卫生—消化系统]