A pilot study on ^(99m)Tc-3PRGD2 scintigraphy in diagnosis of brain glioma  

作　　者：GAO Shi MA Qingjie CUI Qu LIU Lin ZHOU Xueyan JIA Bing CHEN Zuowei ZHANG Haishan 

机构地区：[1]China-Japan Union Hospital,Jilin University [2]Medical Isotopes Research Center,Peking University [3]Department of Nuclear Medicine,People's Hospital of Shenzhen

出　　处：《Nuclear Science and Techniques》2013年第2期36-40,共5页核技术（英文）

基　　金：Supported by the National Natural Science Foundation of China projects(No.81271606);the Research Fund of Science and Technology Department of Jilin province(No.200705327,No.201015185,and No.201201041);the Research Fund of Shenzhen Sci-tech Department of Guangdong province (No.201102154)

摘　　要：The 99mTc-3PRGD2 targeted SPECT/CT scanning was of significance in detecting differentiated glioma.In this work,the diagnostic value of 99mTc-3PRGD2 scintigraphy in brain glioma was evaluated by the ten clinically verified brain glioma patients after obtaining informed consent.The patients first accepted X-ray imaging to localize the detecting regions before administrating with 99mTc-3PRGD2 at a mean radioactivity of 849±115 MBq via single intravenous bolus injection 2 h prior to SPECT/CT imaging.Tumor samples for detectingαvβ3 were collected by surgical operations two weeks after the scintigraphy.The results of CT and SPECT scanning were merged and compared.The correlation between tumor occupation（T/N ratio） andαvβ3 expression level were analyzed.The T/N ratios in brain glioma were proportionally correlated to av(33 positive cell percentage（R2=0.9253,p<0.05）.This study primarily evaluated the clinical application of 99mTc-3PRGD2 SPECT scintigraphy on brain glioma.The more pathological types and detecting strategies covering a large amount of samples would aid to clarify the potentials.The ^99mTc-3PRGD2 targeted SPECT/CT scanning was of significance in detecting differentiated glioma. In this work, the diagnostic value of ^99mTc-3PRGD2 scintigraphy in brain glioma was evaluated by the ten clinically verified brain glioma patients after obtaining informed consent. The patients first accepted X-ray imaging to localize the detecting regions before administrating with ^99mTc-3PRGD2 at a mean radioactivity of 849±115 MBq via single intravenous bolus injection 2 h prior to SPECT/CT imaging. Tumor samples for detecting αvβ3 were collected by surgical operations two weeks after the scintigraphy. The results of CT and SPECT scanning were merged and compared. The correlation between tumor occupation （T/N ratio） and αvβ3expression level were analyzed. The T/N ratios in brain glioma were proportionally correlated to αvβ3 positive cell percentage （R2=0.9253, p〈0.05）. This study primarily evaluated the clinical application of ^99mTc-3PRGD2 SPECT scintigraphy on brain glioma. The more pathological types and detecting strategies covering a large amount of samples would aid to clarify the potentials.

关 键 词：脑胶质瘤 诊断价值 显像 SPECT 扫描检测 X射线成像 临床验证 静脉注射 

分 类 号：R739.41[医药卫生—肿瘤]