水飞蓟宾胶囊治疗抗艾滋病毒药物致肝损害的效果观察  

Efficacy observation of silibinin capsule on liver injury resulted from antiretroviral medicine

作　　者：甄月映[1] 

机构地区：[1]广东省江门市中心医院感染科,广东江门529030

出　　处：《中国当代医药》2013年第15期63-64,66,共3页China Modern Medicine

摘　　要：目的观察水飞蓟宾胶囊对艾滋病患者抗病毒治疗后出现肝损害的疗效。方法将82例诊断为因高效抗逆转录病毒治疗后出现药物性肝炎的艾滋病初治患者随机分成对照组40例和治疗组42例,对照组予口服葡醛内酯片(每次0.2gtid);治疗组在此基础上加用口服水飞蓟宾胶囊(每次70mgtid),疗程2周。结果治疗后两组患者的丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、谷氨酰转肽酶(GGT)均明显下降,治疗组总有效率与对照组相比差异有统计学意义(P<0.05),而且治疗组的ALT、AST、GGT恢复率与对照组相比差异有统计学意义(P<0.05)。结论水飞蓟宾治疗抗艾滋病病毒药物引起的药物性肝炎疗效显著,且用药安全。Objective To observe the clinical effects of silibinin capsule in the treatment of liver function damage resuited from antiretroviral medicine. Methods Eighty-two patients diagnosed as highly active antiretroviral therapy after drug-induced hepatitis appears at the beginning of the HIV/AIDS were randomly divided into the control group （40 cases） and the treatment group （42 cases）. Glucurolactone tablets （0.2 g rid） were given in the control group for 2 weeks. Silibinin capsules （70 mg tid） were given in the treatment group as a supplement to the primary therapy in the control group, treatment for 2 weeks. Results After treatment, ALT, AST and GGT level were significantly decreased in both groups. The total effective rate in treatment group compared with control group, the difference was statistically sig- nificant （P 〈 0.05）. And ALT, AST, GGT recovery rate of treatment group compared with control group , the difference had statistical significance （P 〈 0.05）. Conclusion Silibinin capsule is effective for liver injury caused by antiretroviral medicine. And it is also a safe medicine with less side effects.

关 键 词：药物性肝损害 水飞蓟宾 人类免疫缺陷病毒 抗逆转录病毒治疗 高效 

分 类 号：R575[医药卫生—消化系统]