p53 codon72多态性与乳腺癌风险性的关系  

Genetic polymorphisms of p53codon72 and the risk of breast cancer

作　　者：梁寒梅[1] 刘建萍[2] 王金霞[2] 

机构地区：[1]宁夏医科大学基础学院生物技术系,宁夏银川750004 [2]大庆油田总医院输血科,黑龙江大庆163001

出　　处：《世界最新医学信息文摘》2013年第3期20-21,共2页World Latest Medicine Information Electronic Version

摘　　要：目的探讨p53codon72（＋119C〉G,rs1042522）位点多态性与乳腺癌风险性的关系.方法通过聚合酶链反应-限制性酶切片断多态性方法（PCR-RFLP）检测289例健康对照组和289例乳腺癌患者的p53codon72多态性的基因型.结果基因型CC、CG、GG在乳腺癌组的分布频率分别为29.07%,47.05%、23.87%,在对照组的分布频率分别为20.42%、51.9%、27.68%,两者分布无显著差异（P=0.53）.乳腺癌组中C等位基因和CC基因型的分布均显著高于健康对照组（P〈0.05）.结论 p53codon72多态性与乳腺癌的风险性相关.Objective o study on the relationship of Genetic polymorphisms of p53codon72 with risk of breast cancer. Methods The genotypes of p53codon72 were analyzed by PCR-based restriction fragment length polymorphism（RFLP） method in 289 breast cancer patients and 289 healthy people controls. Results The genotype frequencies for CC, CG, GG were 29.07%, 47.05%,23.87%in breast cancer patients and 20.42%,51.9%,27.68%in healthy subjects, respectively. No significant difference in the distribution of p53codon72 genotype was found between cases and controls（P=0.53）. The frequencies of the C allele and CC genotype were significantly higher in breast cancer patients than in healthy subjects （p〈0.05）. Conclusion p53 codon72 polymorphism is associated with susceptibility of breast cancer.

关 键 词：乳腺癌 P53基因 基因多态性 

分 类 号：R73[医药卫生—肿瘤]