慢性萎缩性胃炎患者体内NF-KB和Bcl-2的表达及意义  

In vivoexpression of NF-KB and Bcl-2 in chronic atrophic gastritis patients and its significance

作　　者：吴继雄[1] 邓亚芳[1] 方亮[1] 

机构地区：[1]湖北省黄冈市中心医院消化内科,湖北黄冈438100

出　　处：《海南医学院学报》2013年第7期895-897,900,共4页Journal of Hainan Medical University

基　　金：中国高校医学期刊临床专项资金项目(112210700)~~

摘　　要：目的:研究慢性萎缩性胃炎患者体内NF-KB(核因子KB)和Bcl-2(B细胞淋巴瘤/白血病-2基因)的表达及意义。方法:采用免疫组织化学SP法检测胃癌患者、慢性非萎缩性胃炎患者、慢性萎缩性胃炎患者胃粘膜中NF-KB和Bcl-2的表达。结果:NF-KB和Bcl-2在各组不同患者中的阳性率呈明显递增趋势,各组间比较差异有统计学意义(P<0.05)。NF-KB和Bcl-2的表达水平在不同肿瘤分化程度、浸润深度、远处转移及淋巴结转移患者中差异有统计学意义(P<0.05)。结论:NF-KB和Bcl-2表达水平的增加与胃癌的发生有重要关系,联合检测NF-KB和Bcl-2的表达,在临床上具有重要诊断意义,及时发现胃癌的早期病变。Objective. To study in vivo expression of NF-KB and Bcl-2 in chronic atrophic gastritis patients and its significance. Methods. Immunohistochemistry SP method were applied to detecte NF-KB and Bcl-2 expression levels in the gastric mucosa of patients with gastric cancer, chronic non-atrophic gas- tritis patients, and atrophic gastritis, respectively. Results. Positive expression rates of NF-KB and Bcl-2 has shown an obvious increasing trend, showing significant differences among the three groups （P〈 0.05）. Expression levels of NF-KB and Bcl-2 were significant different among cases with different severity of tumor differentiation, depth of invasion, lymph node metastasis, or distant metastasis （P〈0.05）. Conclusion. Increased NF-KB and Bel-2 expression levels correlated with the occurrence of gastric cancer,combined detection of the two can help to diagnose early gastric cancer lesions and has essential significance.

关 键 词：慢性萎缩性胃炎 NF—KB BCL-2 胃癌 基因 

分 类 号：R573.3[医药卫生—消化系统]