血清超敏C反应蛋白与非酒精性脂肪肝相关性的性别差异研究  

A Correlative Study of Gender Gap between Serumal High Sensitivity C-reactive Protein and Non-alcoholic Fatty Liver Disease

作　　者：冯京全[1] 梁国威[1] 

机构地区：[1]航天中心医院检验科,北京100049

出　　处：《临床误诊误治》2013年第5期60-63,共4页Clinical Misdiagnosis & Mistherapy

基　　金：航天部航天科工集团科研基金(2011-JKBZ-009)

摘　　要：目的探讨不同性别血清超敏C反应蛋白(hs-CRP)与非酒精性脂肪肝(non-alcoholic fatty liver disease,NAFLD)的相关性。方法选择我院健康体检的2054例按性别分组(男1431例,女623例)进行回顾性调查,除外饮酒、吸烟者及孕妇。脂肪肝采用B型超声进行检测,并采集静脉血检测hs-CRP、血脂、血糖,对比代谢综合征(metabolic syndrome,MS)及NAFLD患病率。结果本研究男、女性NAFLD患病率分别为27.7%和21.7%,差异有统计学意义(P<0.05);男性血压水平,降压、降糖治疗及MS均显著高于女性,差异均有统计学意义(P<0.05)。hs-CRP水平四分位数分组(Q1～Q4组)显示,随hs-CRP分组水平升高,男、女性NAFLD患病率皆呈趋势性升高,差异均有统计学意义(P<0.05)。多元Logistic回归分析显示,控制年龄和体重指数(BMI)后,男性hs-CRP与NAFLD无相关性(P>0.05);控制年龄、BMI和MS后,女性hs-CRP与NAFLD仍具有显著相关性(P=0.025)。结论男、女性血清hs-CRP与NAFLD的相关性具有显著差异,可考虑将hs-CRP作为女性NAFLD患者的一个筛检指标。Objective To explore the correlation of gender gap between serumal high sensitivity C-reactive protein （hs- CRP） and non-alcoholic fatty liver disease （NAFLD）. Methods A retrospective analysis was performed in 2054 health people （ 1431 male and 623 female） in our hospital by physical examinations, not including those who drank alcohol, smoke or were during pregnancy. Fatty liver was examined with abdominal uhrasonography. The hs-CRP, blood fat and glucose were measured by collecting venous blood. Incidence rates of metabolic syndrome （MS） and NAFID by sex-specific prevalence were also compared. Results Incidence rate of NAFLD was significantly different between males （27.7%） and females （21.7%, P 〈0. 05）; blood pressure level, numbers of people who accepted anti-hypertensive and anti-hyperglycemic medication, and numbers of patients with MS in males were significantly higher than those in females （P 〈 O. 05）. When stratified by quartiles of hs-CRP （ Q1 - 04）, incidence rates of NAFLD were significantly increased with the increase of hs-CRP levels in both genders, and the differences were statistically significant （P 〈0. 05）. Muhivariant logistic regression analysis showed that there was no significant correlation between hs-CRP and NAFLD in males after adjustment of age and body mass index （ BM1, P 〉 0. 05） ; after adjustment of age, BMI and MS, hs-CRP was still significantly associated with NAFLD in females （ P = 0. 025 ）. Conclusion There is a significant difference between serumal hs-CRP and NAFLD in enders. The serumal hs-CRP may be suitable in diagnose as NAFLD in females.

关 键 词：脂肪肝 非酒精性 C反应蛋白 性别因素 

分 类 号：R575.5[医药卫生—消化系统]