WT1在晚期浆液性卵巢上皮癌中的表达及意义  被引量:5

The expression and prognostic value of WT1 in advanced serous epithelial ovarian carcinoma

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作  者:劳小斌[1] 刘晓强[2] 邱春嫦[3] 郭飞燕[4] 

机构地区:[1]南方医科大学第三附属医院检验科,广东广州510515 [2]中山大学孙逸仙纪念医院检验科 [3]广州暨南大学附属第一医院检验科 [4]南方医科大学南方医院妇产科

出  处:《中国妇幼保健》2013年第12期1968-1970,共3页Maternal and Child Health Care of China

摘  要:目的:确定晚期浆液性卵巢上皮癌存活与WT1基因表达的相关性。方法:收集2002~2010年经过完整术后化疗的晚期浆液性卵巢上皮癌女性患者168例,最终纳入研究109例。收集入选病例的完整病历资料及石蜡包埋的组织块切片后,WT1免疫染色并据此分组,采用卡普兰-迈耶曲线及COX回归法进行生存分析。结果:55例患者的病理组织WT1染色呈阳性,54例阴性。WT1阳性组的卵巢癌病灶大小和淋巴转移率显著高于WT1阴性组(P<0.05)。WT1阴性患者5年生存率为39.4%,WTI阳性患者5年生存率为10.7%,二者差异有统计学意义(P<0.05)。结论:WT1基因表达与晚期浆液性卵巢上皮癌预后不良密切相关。Objective: To determine the survival and recurrence - free survival of women with advanced serous epithelial ovarian carcinoma in relation to WT1 gene expression. Methods: 168 patients who were diagnosed with advanced serous epithelial ovarian carcinoma and had undergone complete post - operative chemotherapy were selected, but 109 patients were selected into the final study group. The records of these women were reviewed and the paraffin - embedded tissues of these women were stained with WT1 immunostaining. Survival analysis was performed by using Kaplan - Meier and Cox regression methods. Results: Fifty - five patients showed WT1 positive staining and fifty - four did not. Size of residual tumor and lymphatic metastasis rate of WT1 positive expression group were higher than those of WT1 negative expression group (P 〈0. 05) . Five-year survival rate of positive and negative expression of WT1 were 39. 4% and 10. 7% , there was significant difference (P 〈 O. 05 ) . Conclusion: Expression of WT1 gene may be related to unfavorable prognosis of patients with advanced serous epithelial ovarian carcinoma.

关 键 词:WT1基因 浆液性卵巢上皮癌 表达 

分 类 号:R737.31[医药卫生—肿瘤]

 

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