组织型激肽释放酶对脑缺血大鼠神经功能的影响  

Effect on neurological function injury of kallikrein to treat brain ischemia in rat

作　　者：胡明新[1] 边颖[1] 王金春[1] 

机构地区：[1]沈阳市第五人民医院,辽宁沈阳110023

出　　处：《健康大视野（医学版）》2013年第4期234-235,共2页Health Horizon:Medical Science Fascicule

摘　　要：目的研究组织型激肽释放酶（tissue kallikrein，TK）对缺血性脑梗塞大鼠的治疗效果。方法将36只Wistar大鼠随机分配到3组中：空白对照组，盐水对照组（NS2mL·ks^-1·d^-1）；TK组（TK1715×10^-3U·kg^-1·d^-1）。在缺血后8h给药，连续用药3天。在梗死后1、3及7天后对大鼠分别进行神经功能缺失评分。结果TK治疗3天后，与盐水对照组及空白对照组相比，能明显减轻神经功能缺损（P〈0．05）。结论推测TK可能通过增加神经营养因子而对大鼠缺血性脑梗死起治疗作用。Objective To test the effect of tissue kaUikrein on ischemia reperfusion rat.Methods 36 Wistar rats were nmdomly assigned in 3 groups： nothing group,saline group （NS 2mL·ks^-1·d^-1） ,TK treated group（TK1715×10^-3U·kg^-1·d^-1）. The drug was injected after 8 hurs of is- chemia, lasted for 3 days. We assess improvement of at 1,3,7 day after cerebral ischemia. Results Significant recovery of neurological function was found in rats treated with TK comparing with the other two control groups at 3 days after ischemia（ P 〈 0.05）. Conclusions TK has therapeutical effect and increase nerve regeneration of cerebral ischemia zone.

关 键 词：组织型激肽释放酶 缺血再灌注 神经功能缺损 

分 类 号：R743[医药卫生—神经病学与精神病学]