非酒精性脂肪肝纤维化评分与代谢综合征及其各组分的相关性研究  

Relationship of nonalcoholic fatty liver disease fibrosis score with metabolic syndrome and its components

作　　者：王玉[1] 梁军[2] 李洪艳[1] 杨曼青[2] 刘学奎[2] 腾飞[2] 张倩[1] 卞文[3] 

机构地区：[1]徐州医学院,徐州临床学院,徐州221009 [2]徐州市中心医院内分泌科,徐州221009 [3]东南大学医学院

出　　处：《中华内分泌代谢杂志》2013年第5期406-409,共4页Chinese Journal of Endocrinology and Metabolism

摘　　要：以2 544名健康体检人群为研究对象，检测受试者血糖、血脂、血清谷丙转氨酶（ALT）、谷草转氨酶（AST）等相关生化指标。将研究对象按非酒精性脂肪肝纤维化评分（NAFLDFS）的低诊断阈值（-1.455）分成NAFLDFS〈-1.455组（A组）和NAFLDFS≥-1.455组（B组）。结果显示，B组患者年龄、体重、体重指数、腰围、臀围、体脂率、收缩压、舒张压、空腹血糖、餐后2 h血糖、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、ALT、AST、腰臀比水平均高于A组（P〈0.05或P〈0.01）。B组患者代谢综合征、肥胖、高血压、高血糖患病率较A组均明显升高（P〈0.01）。肝纤维化发生率随着代谢综合征组分的增加而增加。提示NAFLDFS是临床较为实用的评估代谢综合征的指标。A total of 2 544 subjects from a community-based health examination survey were included in the present study. Blood glucose, blood lipid, serum alanine aminotransferase （ALT）, and aspartate aminotransferase （AST） were determined. The subjects were divided into nonalcoholic fatty liver disease fibrosis score（NAFLDFS）〈-1.455 group （A group） and NAFLDFS≥-1.455 group （B group） based on the low cutoff of NAFLDFS （-1.455）. The results showed that age, body weight, body mass index, waist circumference, hip circumference, body fat, systolic blood pressure, diastolic blood pressure, fasting blood glucose, postprandial 2 h blood glucose, total cholesterol, triglyceride, low density lipoprotein-cholesterol, ALT, AST, and waist-hip ratio in B group were higher than those in A group （P〈0.05 or P〈0.01）. The prevalences of metabolic syndrome, obesity, hypertension,and hyperglycemia were significantly increased in B group compared with A group （P〈0.01）. The incidence of liver fibrosis increased with the increase of the components of metabolic syndrome. These results suggest that NAFLDFS is a useful clinical index in evaluating metabolic syndrome.

关 键 词：非酒精性脂肪肝纤维化评分 代谢综合征 

分 类 号：R575[医药卫生—消化系统] R589[医药卫生—内科学]