乳腺癌组织KLF5表达临床意义分析  

Analysis of clinical significance of KLF5 expression in breast cancer tissue

作　　者：吕昌新[1] 丁宇[1] 李良[1] 王新美[2] 韩红梅[2] 李新兵[1] 邱树升[1] 

机构地区：[1]滨州医学院附属淄博市中心医院乳腺甲状腺外科,山东淄博255036 [2]滨州医学院附属淄博市中心医院病理科,山东淄博255036

出　　处：《中华肿瘤防治杂志》2013年第11期850-852,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:检测锌指蛋白转录因子5(KLF5)在乳腺癌组织、癌旁组织及腺病组织中的表达,分析其在乳腺癌组织表达水平与临床病理特征的相关性。方法:免疫组化SP法检测100例乳腺癌组织、癌旁组织及20例乳腺腺病组织中KLF5的表达。结果:KLF5在乳腺癌细胞染色呈阳性,镜下可见大量棕褐色颗粒位于癌细胞胞质内,细胞核不被着色。癌旁组织和腺病组织可见棕黄色颗粒。100例乳腺癌组织中,KLF5的阳性表达率为74.0%(74/100),明显高于癌旁组织阳性表达率48.0%(48/100),差异有统计学意义,χ2=14.208,P=0.000;100例乳腺癌组织KLF5的阳性表达率,明显高于20例腺病组织阳性表达率35.0%(7/20),差异有统计学意义,χ2=11.556,P=0.001;乳腺癌旁组织阳性表达率与腺病组织比较,差异无统计学意义,χ2=1.135,P=0.287。KLF5在乳腺癌及癌旁组织中的表达情况与肿瘤大小差异有统计学意义,χ2=3.904,P=0.048,但与乳腺癌的病理类型、淋巴结转移、病理分级、ER及c-erbB-2等差异无统计学意义,P>0.05。结论:KLF5在乳腺癌组织中高表达,并且与肿瘤大小密切相关,但与乳腺癌的病理类型、淋巴结转移、病理分级及激素受体无关。KLF5有可能成为预测乳腺癌发生发展的重要肿瘤标志。OBJECTIVE：By detecting the expression of KLF5 in breast cancer tissues,adjacent tissues and breast ad- enosis tissues,to analyze the relationship between the expression level of KLF5 in breast cancer and clinical characteris- tics. METHODS： By using immunohistochemistry methods the expressions of KLF5 in 100 cases of breast cancer tissues, 100 cases of adjacent tissues and 20 cases of breast adenosis tissues were detected. RESULTS：KLF5 staining was positive in breast cancer cells＇, there were large number of brown granules in the cytoplasm of cancer cells under microscope, and the nucleus were not being shaded. There were tan visible particles in adjacent to carcinoma and adenosis tissues. The positive expression rate of KLF5 in breast cancer tissues was 74.0 % （74/100） ,and it was dramatically higher than that in the adjacent tissues （48/100,48.0%, X2 = 14. 208, P= 0. 000）;The positive expressions of KLF5 in breast cancer tissues were dramatically higher than that in breast adenosis tissues （35.0 %, 7 / 20, ;（2 = 11.556, P = 0.001 ） ; There was no differ ence between the adjacent tissues and breast adenosis tissues（;（2 = 1. 135, P= 0. 287）. The tumor size had definite rela- tionships to the expressions of KLF5 in breast cancer and adjoining tissues （;（2 = 3. 904, P = 0. 048）. However, it had no significant difference with the pathological type of breast cancer, lymph node metastasis, pathological grading, or status of ER and c-erbB-2. CONCLUSIONS： KLF5 is highly expressed in breast cancer tissues,which is closely related to the tumor sizes,and had no relationship with the pathological type of breast cancer,lymph node metastasis, pathological grading and hormone receptors. KLF5 may possiblly becomes an important tumor marker to predict breast cancer development.

关 键 词：乳腺肿瘤 病理学 锌指蛋白转录因子5 转录因子 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]