补心益胆、安神定志法治疗163例惊恐障碍疗效观察  

The Short-term effect of Nourishing heart and gallbladder to Calm down the Spirit in the Treatment of 163 Panic Disorder Cases

作　　者：杨国华[1] 李宁[1] 吴晓青[2] 顾秀玲[3] 董涛[1] 董永丽[1] 易璐莹[1] 王志平[1] 赵腾腾[1] 林兰梅[1] 赵玲茏[1] 

机构地区：[1]中国中医科学院望京医院,北京100102 [2]北京中医药大学东方医院,北京100078 [3]首都医科大学附属北京朝阳医院,北京100020

出　　处：《中国中医基础医学杂志》2013年第5期594-596,共3页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：首都医学科技发展科研基金课题-补心益胆;安神定志法治疗心胆气虚型惊恐障碍的临床研究(SF-2009-Ⅲ-07);中国中医科学院第三批优势病种项目(CACMS08Y0017)

摘　　要：目的:观察补益心胆、安神定志法治疗惊恐障碍的疗效。方法:将163例患者随机分成2组,治疗组给予补益心胆安神定志方口服,对照组给予帕罗西丁口服,4周为1个疗程,观察比较2组患者治疗前后HAMA及SAS变化情况。结果:试验组总体疗效的有效率高于对照组,有统计学意义(P<0.05);对照组HAMA总分改善优于对照组,从治疗第3天起试验组总分改善优于对照组(P<0.05)。试验组患者的SAS总分改善优于对照组,从治疗第3天起2组改善差异有统计学意义(P<0.05)。试验组口干、便秘等消化系统副反应的发生率低于对照组,组间差异有统计学意义(P<0.05)。结论:补益心胆、安神定志法治疗惊恐障碍疗效确切,与对照组没有显著差异,且起效较早、副作用较对照组少。Abstract Objective：To To observe the efficacy of the TCM treatment of ＂nourishing qi of the heart and gallbladder to calming down the shen＂ to cure for the panic disorder. Methods： 163 standard clinical cases were divided into test and control groups at random. The test group assigned to receive Anshendingzhifang; the control group assigned to receive seroxat （Paroxetine Hydrochloride Tablets）. The course of treatment was 4 weeks. To observe and compare the changes of the score of HAMA and SAS before and after treatment. Results： The differences had statistical significance in the total effect between two groups（ P 〈 0.05） ,the effect of test group was better than control group;the score of HAMA and SAS in test group decreased more significantly than control group , especially, after three days treatments, the differences had statistical significance between two groups （ P 〈 0.05）. The incidence of gastrointestinal symptom just like dry mouth , constipation etc of test group was lower than that of control group,the difference was statistically significant（P 〈 0.05 ）. Conclusion ： The therapy of ＂nourishing qi of the heart and gallbladder to calming down the shen＂ to cure for the panic disorder has a satisfactory curative effect, the difference was statistically significant. However, the effect of the treatment of test group was earlier than control group ,and the the incidence of side-effects was lower.

关 键 词：补益心胆 安神定志 惊恐障碍 临床观察 

分 类 号：R749.72[医药卫生—神经病学与精神病学]