新型含噻唑环的吡唑肟醚类衍生物的合成及其生物活性  

Synthesis and Bioactivities of Novel Pyrazole Oxime Ether Derivatives Containing a Thiazolyl Moiety

作　　者：戴红[1,2] 于海波[1] 刘建兵[1] 秦雪[1] 王婷婷[1] 张欣[1] 秦振芳[1] 方建新[1] 

机构地区：[1]南开大学元素有机化学国家重点实验室,天津300071 [2]南通大学化学化工学院,南通226019

出　　处：《有机化学》2013年第5期1104-1107,共4页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.20772068;21202089);南通大学引进人才基金(No.12R036)资助项目~~

摘　　要：为了寻找活性较好的杂环农药,将噻唑基团引入到吡唑分子结构中,设计合成了一系列新型含噻唑环的吡唑肟醚衍生物.通过1H NMR、13C NMR和元素分析测试对标题化合物的结构进行了表征.对合成的目标化合物进行了初步的生物活性测试,部分化合物显示出一定的的杀菌、杀虫或植物生长调节活性.In order to find potent pesticide containing heterocycle, a series of novel pyrazole oxime ether derivatives contain- ing a thiazolyl moiety were designed and synthesized by introducing the significant thiazole ring into the molecular structure of pyrazole. The structures of these compounds were characterized by 1H NMR, 13C NMR spectra and elemental analysis. Bioactivities of the target compounds were performed, and some compounds exhibited certain fungicidal, insecticidal or plant growth regulatory activities.

关 键 词：吡唑肟 噻唑 合成 生物活性 

分 类 号：TQ463.5[化学工程—制药化工]