副流感病毒基因工程研究进展  

Reaserch Progress on Parainfluenza Virus Genetic Engineering

作　　者：曹丽[1,2] 师新川[2] 高维凡[1] 温永俊[2] 

机构地区：[1]沈阳农业大学,辽宁沈阳110161 [2]中国农业科学院特产研究所,吉林长春130122

出　　处：《中国畜牧兽医》2013年第5期185-189,共5页China Animal Husbandry & Veterinary Medicine

基　　金：国家863项目"新型重大动物疫病疫苗与诊断试剂创制及生产工艺创新"(2011AA10A213);吉林省特种经济动物疫病防控研究创新团队(20121823)

摘　　要：副流感病毒是一类不分节段的单股负链RNA病毒,按基因型可分为1、2、3、4和5型,5个型之间有少量的交叉免疫,各型的生物学特性和结构类似。该病毒宿主谱广,可感染人、牛和犬等多种动物。副流感病毒具有许多优良的特性,可作为活病毒疫苗的候选载体,通过反向遗传操作系统可使其表达外源基因,研发新型疫苗。作者在综述副流感病毒病原学、基因组结构及主要蛋白质等生物学特征的基础上,着重介绍了副流感病毒作为病毒载体在基因工程方面的研究进展。The parainfluenza virus is a nonsegmented negative-strand RNA virus（NNSV）,according to the genetic type,it is divided into 1,2,3,4 and 5 types,the fourth type can be divided into 4a and 4b subtypes,five types have bits of cross immunity.Biological characteristics and structures of each type are similar.The host range of parainfluenza virus is wide,it can infect human,canine,cattle and many others animal.The parainfluenza virus has a number of feature that make them attractive candidates as live virus vectors.The vectors can express foreign antigen,as a new vaccine by the reverse genetic system.This review will focus on the genetic engineering research development of parainfluenza virus as virus vectors,including antigenic,genetic structure,biological characteristics and so on.

关 键 词：副流感病毒 基因 研究进展 

分 类 号：S852.659.5[农业科学—基础兽医学]