D2-40标记食管鳞癌淋巴管浸润的检测及其临床病理意义  

Detection of D2-40 monoclonal antibody-labeled lymphatic vessel invasion in esophageal squamous cell carcinoma and its clinicopathologic significance

作　　者：白冰[1] 马伟[1] 王凯 哈斯塔 王建波[1] 谭炳煦[1] 王娜娜[1] 杨圣思[1] 贾亦斌[1] 程玉峰[1] 

机构地区：[1]山东大学齐鲁医院放疗科,济南市250012 [2]文登市中心医院 [3]熊本大学医学部细胞病理科

出　　处：《中国肿瘤临床》2013年第9期543-546,共4页Chinese Journal of Clinical Oncology

基　　金：山东省科技发展计划项目基金(编号:2012GGE27088);中国博士后科学基金(编号:2011M500531)资助~~

摘　　要：目的:探讨D2-40标记食管鳞癌淋巴管浸润(LVI)的临床病理意义。方法:应用免疫组织化学S-P法检测107例食管鳞癌D2-40蛋白表达并观察淋巴管受肿瘤细胞浸润的情况,分析其与食管鳞癌临床病理因素之间的关系,观察患者总生存期。结果:食管鳞癌组织LVI阳性组淋巴结转移率70%,LVI阴性组淋巴结转移率21%,LVI阳性组转移率高于阴性组,多因素分析显示两组间差异有统计学意义(P<0.001)。LVI阳性组中位生存时间为26个月,LVI阴性组中位生存时间43个月,单因素分析显示两组间差异有统计学意义(P=0.014),多因素分析显示LVI不能成为食管鳞癌术后患者预后的独立危险因素(P=0.062),淋巴转移(P=0.031)、临床分期(P=0.019)和肿瘤残留(P=0.026)是预后的独立危险因素。结论:D2-40标记的LVI可以预测食管鳞癌患者的淋巴结转移。Objective：This study aims to investigate the clinicopathological significance of lymphatic vessel invasion （LVI） la-beled by D2-40 monoclonal antibody in esophageal squamous cell carcinoma （ESCC）. Methods：Immunohistochemical assay was used to detect the expression of D2-40 and LVI in 107 ESCC cases. Then, the correlation between the clinicopathological feature and the overall survival time in patients was analyzed. Results：The lymph node metastasis rates were 70%and 21%in the LVI-positive and LVI-negative groups, respectively. The nodal metastasis rate was higher in the LVI-positive group than in the LVI-negative group. Mul-tivariate regression analyses showed that LVI was related to nodal metastasis （P〈0.001）. The median survival times of the patients were 26 and 43 months in the LVI-positive and LVI-negative groups, respectively. Although the univariate regression analysis showed signifi-cant difference between the two groups （P=0.014）, the multivariate regression analyses revealed that LVI was not an independent prog-nostic factor for overall survival in the ESCC patients （P=0.062）. Lymphatic node metastasis （P=0.031）, clinical stage （P=0.019）, and residual tumor （P=0.026） were the independent prognostic factors. Conclusion： LVI labeled by D2-40 monoclonal antibody is a risk factor predictive of lymph node metastasis in ESCC patients.

关 键 词：食管鳞癌 淋巴管浸润 D2-40 淋巴结转移 预后 

分 类 号：R735.1[医药卫生—肿瘤]