Adipophilin介导脂质蓄积及炎症反应的研究进展  

Adipophilin Mediated Lipid Accumulation and Inflammation Reaction Research Progress

作　　者：陶媛[1] 郭东铭[1] 袁中华[1] 

机构地区：[1]南华大学心血管病研究所动脉硬化学湖南省重点实验室,湖南省衡阳市421001

出　　处：《中国动脉硬化杂志》2013年第5期472-476,共5页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金(No30971268);教育部留学回国人员科研启动基金(教外司留〔2008〕89号)

摘　　要：脂质蓄积与炎症反应在动脉粥样硬化中发挥关键作用,两者相互促进,相互影响。而Adipophilin作为胞浆脂滴的一种不完全包被蛋白,不仅可以作为动脉粥样硬化脂质蓄积的一种标记物,而且能够促进脂质蓄积、抑制细胞内胆固醇外流,并介导TNF-α、MCP-1和IL-6等炎症介质分泌,其表达受核受体、脂肪酸、修饰脂蛋白、激素类物质等多种因素的调控。本文就Adipophilin在脂质蓄积与炎性反应中的作用及其调控做一简要综述,为通过调控Adipophilina防治动脉粥样硬化提供新的思路。Lipid accumulation and inflammatory reaction play a key role in the process of atherosclerosis, which promote and influence each other. The Adipophilin as cytoplasmic lipid droplets of imperfect-coating protein, not only can be used as a marker of atherosclerotie lipid accumulation, but also can promote lipid accumulation, and inhibit the efflux of intracellular cholesterol, and mediate the secretion of some inflammatory mediators, such as TNF-α, MCP-1 and IL-6, and its expression is regulated by various factors, like the nuclear receptors, fatty acid, modified lipoprotein and hormone-like substance. The purpose of this paper is to make an overview of how Adipophilina plays a role in lipid accumulation and inflammatory response in order to help find a new thought about preventing Atherosclerosis through regulating.

关 键 词：ADIPOPHILIN 脂滴 脂质蓄积 炎症反应 动脉粥样硬化 

分 类 号：R363[医药卫生—病理学]