波形蛋白作为肿瘤治疗新靶点的研究进展  

Using vimentin as a potential molecular target for cancer therapy:recent progress

作　　者：曹效忠[1] 李瑾[1] 郭宝良[1] 

机构地区：[1]哈尔滨医科大学附属第二医院乳腺外科,黑龙江哈尔滨150086

出　　处：《中国普通外科杂志》2013年第5期643-648,共6页China Journal of General Surgery

摘　　要：波形蛋白(vimentin)是中间丝蛋白家族的重要一员,在多种肿瘤组织中表达增加。笔者就vimentin作为肿瘤治疗新靶点的研究进展作一综述,主要内容包括:vimentin的分泌和调节及其在细胞器的分布和在细胞表面的运输;vimentin与信号通路的关系;vimentin表达与多种癌症的关系以及vimentin的药物靶点。Vimentin is an important member of the intermediate lament（IF） proteins family,which has been found to be overexpressed in a variety of tumors.is paper overviews the progress in researches concerning vimentin as a novel molecular target for cancer therapy and the main contents include： the secretion and regulation of vimentin,and its subcellular distribution and export to cell surface;relationship between vimentin and cell signaling pathways;relations of vimentin with various cancers and the target sites of vimentin for drugs.

关 键 词：肿瘤 波形蛋白 靶向治疗 综述文献 

分 类 号：R730.5[医药卫生—肿瘤]