弥漫大B细胞淋巴瘤中医体质分布及其与预后的相关性  

Correlation between Distributions of Traditional Chinese Medicine Constitution with Diffuse Large B-cell lymphoma Prognosis

作　　者：郑秦[1] 杜美莲[2] 罗梅宏[1] 夏乐敏[1] 董英[3] 周永明[2] 王运律[1] 胡琦[1] 

机构地区：[1]上海中医药大学附属市中医院,上海200071 [2]上海中医药大学附属岳阳中西医结合医院,上海200437 [3]上海中医药大学,上海201203

出　　处：《辽宁中医药大学学报》2013年第6期71-75,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：上海市卫生局中医药科研基金项目(2010L040A)

摘　　要：目的:探讨弥漫大B细胞淋巴瘤(Diffuse large B-cell lymphoma,DLBCL)中医体质分布,分析中医体质与DLBCL预后的关系。方法 :收集受试者病例资料,包括基本信息、初诊时间、病灶部位、血清LDH、骨髓累及情况、病理活检、免疫组化、化疗方案等,采用标准化的9种中医体质分类量表进行中医体质评价,对结果进行统计分析。结果 :共收集76例患者,平和质24例(约占31.6%),偏颇质52例(约占68.4%);在偏颇质中,阳虚质27例(51.9%)>气虚质10例(19.2%)>气郁质6例(11.5%)>特禀质5例(9.7%)>阴虚质3例(5.8%)>血瘀质1例(1.9%);68例进行了6次化疗后的疗效评估,偏颇质CR率(68.9%)明显较和平质(39.1%)高(P<0.05);阳虚质、气郁质、阴虚质、气虚质、特禀质、血瘀质CR率分别为80.0%、75.0%、50.0%、66.7%、25.0%、0,各偏颇质类型间及与平和质间比较,均无统计学意义(P>0.05)。结论 (:1)DLBCL患者体质或以偏颇质为多,且阳虚体质最多;(2)中医体质与DLBCL预后有相关性,偏颇体质预后较和平质佳。Objective： To investigate the distribution and influence of traditional Chinese medicine constitution （TCMC） on diffuse large B-cell lymphoma（DLBCL）. Methods ： Case !datum of patients with DLBCL were collected including essential information, initial diagnosis time, focal areas, serum LDH values, bone marrow involvement situation, pathological findings, ＇immunohistochemical results, chemotherapy regiments, etc. Chinese medicine constitution types were determined by TCMC questionnaire （TCMCQ）.The results were analyzed with the multivariate logistic regression analysis. Results ： 76 cases were analyzed. The gentler in TCMC was 24 （31.6%）. The biased was 52 （68.4%）, including Yang-deficiency 27 cases （51.9%）, Qi-deficiency 10 （19.2%）, Qi-depression 6 （11.5%）, the intrinsic quality 5 （9.7%）, Yin-deficiency 3 （5.8%） and the blood-stasis type 1（1.9%）. 67 cases of them were evaluated after 6 regimens. CR ratio of the biased （68.9%） was much higher than the gentler （39.1%） （P〈0.05）. CR ratio of Yang-deficiency, Qi-depression, Yin-deficiency, Qi-deficiency, the intrinsic quality and the blood-stasis was respectively 80.0%, 75.0%, 50.0%, 66.7%, 25.0%, 0. There was no statistic difference among all kinds of the biased constitution and the gentler. Conclusions ： It was possible that patients with DLBCL were mainly the biased constitution, especially the Yang-deficiency.And there was correlation between TCMC with DLBCL prognosis. Compared with the gentler, the biased had better prognosis.

关 键 词：弥漫大B细胞淋巴瘤 中医体质 预后因素 

分 类 号：R733[医药卫生—肿瘤]