新老产地川芎中酚酸类成分的含量比较及川芎等级划分内涵研究  

Comparison of the Content of Phenolic Acids in Ligusticum chuanxiong from New and Traditional Producing Areas and the Connotation of Division Grades

作　　者：银玲[1] 彭月[1] 陈鸿平[1] 刘荣[1] 樊丹青[1] 刘友平[1] 

机构地区：[1]成都中医药大学药学院中药资源系统研究与开发利用省部共建国家重点实验室培育基地,成都611137

出　　处：《中国实验方剂学杂志》2013年第11期91-94,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：四川省教育厅科技支撑计划项目(2011SZ0068)

摘　　要：目的:分析川芎个重与其有效成分相关性,揭示川芎等级划分的内涵;比较新老产地川芎中阿魏酸、总酚酸的含量,为川芎的质量控制提供参考。方法:采用高效液相色谱法测定新老产地川芎中阿魏酸含量;采用紫外分光光度法,以没食子酸为对照品测定新老产地川芎中总酚酸含量;采用SPSS软件分析川芎个重与其阿魏酸、总酚酸相关性。结果:新老产地川芎中阿魏酸含量为0.173 4%～0.312 9%,总酚酸含量为0.978 6%～1.472 3%,新老产地川芎的阿魏酸、总酚酸含量差异较小,川芎个重与其阿魏酸含量呈正相关关系。结论:新老产地川芎中阿魏酸、总酚酸含量没有明显差异,表明新新产地与老产地适宜川芎的栽培种植,可通过新新产地的引种栽培来缓解药材的供需矛盾;川芎药材平均个重与阿魏酸含量呈正相关关系,该结论揭示了川芎等级划分的内涵,为中药材等级划分提供了理论支撑。Objective： To analyze the correlation between the average weight of Ligusticum chuanxiong and the content of effective components, thus revealing the connotation of grades division of L.chuanxiong, and compare the content of ferulic acid, total phenolic acids in L.chuanxiong from new and traditional producing areas, thus providing references for the quality control of L.chuanxiong. Method： HPLC was adopted to determine the content of ferulic acid in L.chuanxiong from new and traditional producing areas. UV spectrophotometry was adopted to determine the content of total phenolic acids with gallic acid as reference. SPSS software was adopted to analyze the correlation between the weight of L.chuanxiong and the content of ferulic acid and total phenolic acids. Result： The content of ferulic acid in L.chuanxiong from new and traditional producing areas was 0.173 4% to 0.312 9%, while the content of total phenolic acids was 0.978 6% to 1.472 3%. There were small differences between the content of ferulic acid and total phenolic acids in L.chuanxiong from different producing areas. The average weight of L.chuanxiong had a positive correlation between the content of ferulic acid. Conclusion： There were no significant differences between the content of ferulic acid and total phenolic acids, showed that the new and traditional producing areas all were suitable for the cultivation of L.chuanxiong, and the imbalance between supply and demand of L.chuanxiong could be relieved by introduction cultivation. The average weight of L.chuanxiong had a positive correlation between the content of ferulic acid, thus revealing the connotation of grades division of L.chuanxiong and providing theoretical supports for its grades division.

关 键 词：川芎 相关性 阿魏酸 总酚酸 新老产地 

分 类 号：R284.1[医药卫生—中药学]