原发性干燥综合征患者抑郁障碍与生活事件的相关性研究  

A correlation study on depression and life events of patients with primary sjogren syndrome

作　　者：杨敏[1] 周润华[1] 莫汉有[1] 高东[2] 梁胜翔 戴小良[4] 刘荣[5] 

机构地区：[1]桂林医学院附属医院风湿免疫科,桂林541001 [2]桂林医学院附属医院精神心理科,桂林541001 [3]空军空降兵学院门诊部 [4]解放军第一八一医院风湿免疫科 [5]解放军第一八一医院精神心理科

出　　处：《中华行为医学与脑科学杂志》2013年第5期400-402,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金资助项目（81160376）;广西壮族自治区卫生厅课题（Z2010303）

摘　　要：目的探讨原发性干燥综合征（PSS）患者抑郁障碍与生活事件的关系。方法采用抑郁自评量表（SDS）及生活事件量表（LES），对80名诊断为抑郁障碍的PSS患者（研究组）抑郁状态及生活事件进行评定，同时按照研究组的年龄、性别构成，选取80名排除合并抑郁障碍的PSS患者（对照组）进行对照，并对研究组的生活事件及抑郁状态进行相关分析。结果研究组患者经历的生活事件总值、负性生活事件值、SDS评分及生活事件频率[分别为（32．72±13．93）分，（24．36±11．24）分，（58．60±16．78）分，91．3％]均高于对照组[分别为（26．96±11．62）分，（15．88±9．97）分，（39．34±14．69）分，40％]，差异具有统计学意义（P〈0．05），正性生活事件值[（7．15±5．84）分]低于对照组[（9．76±7．29）分]，差异具有统计学意义（P〈0．05），负性生活事件主要表现在家庭生活及工作学习方面；相关分析发现，研究组的负性生活事件值及生活事件总值与抑郁程度均呈显著正相关（P〈0．01），而正性生活事件值与抑郁程度则呈负相关（P〈0．05）。结论PSS合并抑郁障碍患者经历更多的负性生活事件，负性生活事件在其抑郁障碍的发病过程中起着重要作用。Objective To explore the relationship between life events and depression of patients with primary sjgren＇s syndrome （PSS）. Methods 80 patients with PSS complicating depressive disorder were tested by self-rating depression scale（SDS） and life event scale（LES） , and compared with the control group including 80 PSS patients with non-depressive disorder matched with age and sex. Then the correlation between SDS and LES were analyzed. Results The total score of life events （32.72 ± 13.93 ）, the score of negative life events （24.36 ± 11.24）, the score of SDS（58.60 ± 16.78 ） and the frequency of life events （91.3% ） in the research group were higher than those in control group （P 〈 0.05 ）, but the positive life events score （7.15 ±5.84） was lower than that in control group（9.76 ± 7.29）,and there was statistically significant difference between the two groups （P 〈 0.05 ） , there were more negative life events, especially on the aspects of family, work and study in the research group. There was positive correlation among the negative life events score, total score of life events and SDS score in the research group（P〈 0.01 ） , meanwhile, negative correlation was revealed between the score of positive life events and SDS score in the research group（P 〈 0.05 ）. Conclusion Patients with PSS complicating depressive disorder experienced more negative life events which play an important role in depression of patients with PSS.

关 键 词：原发性干燥综合征 抑郁障碍 生活事件 

分 类 号：R749.4[医药卫生—神经病学与精神病学]