68例血管母细胞瘤的组织病理及免疫组化研究  

A Histopathologic and Immunohistochemical Study of 68 Cases o f Hemangioblastoma

作　　者：胡颖川[1] 庞宗国[1] 王庆茹[1] 杨光华[1] 成娘[1] 

机构地区：[1]华西医科大学附属第一医院病理科,成都610041

出　　处：《华西医科大学学报》2000年第3期380-382,共3页Journal of West China University of Medical Sciences

摘　　要：为了解血管母细胞瘤的病理形态变化特点及其间质细胞的组织来源 。对68例 血管母细胞瘤进行了组织形态学观察，并对33例进行了免疫组化染色。52例（76.6%）病程 在2月至1年之间，60例（88.2%）发生于小脑，50例（73.5%）呈囊性包块。从组织形态上可 将该瘤分为三型：经典型30例，富于细胞型21例，网状型17例。33例血管母细胞瘤的间质细 胞均对神经特异性烯醇酶（NSE）阳性，而对八因子（F-Ⅷ）、荆豆凝集素1（UEA-1）、 神 经胶质酸性蛋白（GFAP）、上皮膜抗原（EMA）均阴性。结论：血管母细胞瘤的病理形态改 变有三种基本类型；该肿瘤中的间质细胞对NSE阳性，但对F-Ⅷ、UEA-1、GFAP、EMA阴性 ，很可能具有神经内分泌分化的特点。The aim of this study was to evaluate the histologic character isti cs of hemangioblastoma (HB) and investigate the histogenesis of its stromal cell s. Sixty-eight cases of hemangioblastoma were studied by light microscopy and t h irty-three cases were examined by immunohistochemical stainning. Forty-eight o f the 68 patients were males and 20 were females. The average age was 37. Fifty-t w o cases (76.6%) had been present for two months to one year before the diagnosis was made. Sixty cases (88.2%) arose in the cerebellum. Fifty cases (73.5%) app e ared as cystic nodules. Histologically, the 68 cases of HB were further categori zed into three subtypes: typical (30 cases), cellular (21 cases) and reticular ( 17 cases). In 33 cases, the stromal cell were positive for NSE, but negative for F-Ⅷ, UEA-1, GFAP and EMA. In summary, there are three essential histologic c at egories of hemangioblastoma, and its stromal cells may well have the characters of neuroendocrine differentiation.

关 键 词：血管母细胞瘤 组织病理学 免疫组织化 间质细胞 

分 类 号：R739.410.2[医药卫生—肿瘤]