中国3766例非综合征性总唇裂的分析  

Nonsyndromic Cleft Lip with or without Cleft Palate in Chinese Popula tion: Analysis of 3766 Cases

作　　者：梁娟[1] 王艳萍[1] 缪蕾[1] 朱军[1] 周光萱[1] 吴艳乔[1] 

机构地区：[1]华西医科大学附属第二医院中国出生缺陷监测中心,成都610041

出　　处：《华西医科大学学报》2000年第3期408-410,共3页Journal of West China University of Medical Sciences

摘　　要：为了解我国1988～1992年非综合征性总 唇裂的流行病学特征及发生率的动态 变化趋势，采用以医院为单位的整群抽样方法，对全国500所医院孕28周至产后7天的3 246 408例围产儿，3 766例非综合征性总唇裂病例进行回顾性分析。结果：我国非综合征性总唇 裂发生率为11.6/万，其中单纯性唇裂为3.8/ 万，唇裂合并腭裂为7.8/万，5年发生率无显 著性差异（P＞0.1）。城乡非综合征性总唇裂的发生率（11.7/万，11.4/万）无明显差 异（ P＞0.5）；男性发生率（13.3/万）高于女性（ 9.5/万)，P＜ 0.01。性别比为1 .6∶1。在3766 例唇裂中，唇裂合并腭裂占67％，单侧性唇裂合并腭裂占43％，单侧性唇裂占28％。左侧唇 裂合并腭裂和左侧唇裂分别为29％、21％。 结果提示：1988～1992年我国非综合征性总唇 裂 发生率无变化趋势，城乡无差异，男性易感性大于女性。唇裂合并腭裂较常见，单侧病例居 多，以左侧为主。A retrospective study was conducted to evaluate the variation tre nd in the incidence and epidemiological characteristics of nonsyndromic cleft li p with or without cleft palate in Chinese population. From 1988 to 1992, data w e re collected from more than 500 hospital-based units involved in a monitoring p r ogram and were analyzed by the National Center for Birth Defects Monitoring. The monitored subjects were the hospitalized births from 28 weeks gestation to a pe riod within 7 days after delivery, which included 3246 408 perinatals and 3766 cases. The total incidence of nonsyndromic cleft lip with or without cleft pala te was 11.6/10 000； the total incidence of celft lip alone was 3.8/10 000 and t hat of cleft lip with cleft palate was 7.8/10 000; no significant variation was noted in the annual incidence from 1988 to 1992. The incidence in males was 13 3/10 000, and 9.5/10 000 in females; there was a significant difference (P＜ 0.01 ). Of all the 3766 cases , cleft lip with cleft palate accounted for 67%, unila teral cleft lip 28% and unilateral cleft lip with cleft palate 43%. Left cleft l ip and left cleft lip with cleft palate constituted 21% and 29% respectively. T he sexratio was 1.6∶1 for nonsyndromic cleft lip with or without cleft palate . It could be concluded that the incidence of nonsyndromic cleft lip with or witho ut cleft palate showed no variation trend in China. Although no difference was f ound between urban and rural areas, the susceptibility to the defect was higher in males than in females. Cleft lip with cleft palate was more common than other types. There was a predominance of unilateral defects, of which most were on th e left side.

关 键 词：唇腭裂 非综合征性总唇裂 发生率 流行病学 

分 类 号：R782.2[医药卫生—口腔医学]