富硒麦芽冲剂对小鼠免疫功能的影响  

Study on the Effect of Se-rich Malt Granules on the Immunity Function of Mice

作　　者：张荣泉[1] 吕方[1] 赵亚新[1] 罗威[1] 郭大生 

机构地区：[1]天津市医药科学研究所,天津300020 [2]天津市新天马企业发展有限公司,天津300221

出　　处：《食品研究与开发》2013年第7期1-5,共5页Food Research and Development

摘　　要：利用麦苗对无机硒富集转化为有机硒,制备成冲剂,通过动物试验来观察其对小鼠免疫功能的调节作用。用富硒麦芽粉为原料制备成富硒麦芽冲剂,试验动物分3个剂量组(1.0、2.0、4.0 g/kg.BW),称取样品用蒸馏水混合,同时设蒸馏水对照组,各组灌胃量为每天0.2 mL,连续30 d。测小鼠细胞免疫与体液免疫相关指标,并对其进行统计分析。HC50试验高剂量组结果高于对照组(P<0.05),抗体生成试验的中、高剂量组抗体生成细胞数高于对照组(P<0.05);小鼠迟发性变态反应试验显示,高剂量组小鼠攻击前后足跖厚度差值高于对照组(P<0.05);NK细胞活性检测,中、高剂量组NK细胞活性高于对照组(P<0.05)。提示富硒麦芽冲剂具有增强小鼠免疫力功能的作用。To investigate the Se-rich malt granules effects on immune function in mice, which the Se-rich malt was transformed from inorganic Se. Mice were randomly selected and divided into 3 groups ： control group, Serich malt groups with the dose of t.0,2.0,4.0 g/kg· BW by oral administration for 30 d respectively. The cellular immunity and humoral immunity of mice were tested. HC50 value of the high group mice increased （P〈0.05）, hemolytic antibody of high and middle groups were significantly increased markedly （P〈0.05）, the delayed type hypersensitivity （DTH） were better than that of the control group （P〈0.05）, NK cells activities of the high and middle groups were strengthened （P〈0.05）. Se-rich malt granules can promote mice immunity.

关 键 词：有机硒 富硒麦芽冲剂 小鼠 免疫功能 

分 类 号：R285.5[医药卫生—中药学]