不同心肌病充血性心力衰竭患者细胞因子的变化  

A study of cytokines in different cardiomyopathy in heart failure

作　　者：宋浩明[1] 罗明[1] 邓南伟 邹颂海[1] 邓兵 刘健[1] 夏芝芸 

机构地区：[1]同济大学医学院附属甘泉医院心内科,上海200065

出　　处：《临床心血管病杂志》2000年第8期340-342,共3页Journal of Clinical Cardiology

摘　　要：目的 :探讨细胞因子在不同心肌病充血性心力衰竭 (CHF)中升高的触发机制。方法 :选择不同心肌病CHF患者 6 0例 (缺血性心肌病和扩张型心肌病各 30例 ) ,并选择 30例匹配的正常人作为对照组 ,放射免疫法检测肿瘤坏死因子 - α(TNF- α)、白细胞介素 - 1 (IL- 1 )、IL- 6和神经激素〔醛固酮 (AL D)、心钠素 (ANP)、肾素 (PRA)、血管紧张素 (AT )〕。结果 :TNF- α、IL- 1、IL- 6在 CHF患者中较正常人明显增高 (P <0 .0 0 1 )。不同心肌病CHF患者 ,在相同心功能分级时细胞因子水平无显著性差异。 TNF- α的升高与 ANP水平以及 IL- 6的升高与AL D水平均呈正相关。结论 :细胞因子在 CHF中起重要作用 ;但与不同心肌病无关。Objective:To study the mechanism of the elevation of TNF α,IL 1 and IL 6 in heart failure caused by different cardiomyopathies.Method:Baseline concentration of TNF α,IL 1 and IL 6 and neurohormones were measured from peripheral venous plasma in 30 healthy control and 60 adult cardiac patients (30 with idiopathic dilated cardiomyopathy and 30 with ischemic cardiomyopathy).Result:Plasma levels of TNF α, IL 1 and IL 6 were significantly elevated in heart failure patients than those in age matched control subjects (P< 0.001 ).Cytokine concentrations did not differ in the same NYHA function classification in heart failure patients of different cardiomyopathies.Elevated plasma levels of TNF α and IL 6 were positively correlated with atrial natriuretic polypeptide (ANP) and aldosterone (ALD) separately.Conclusion:The cytokines play an important role in the pathogenesis of chronic heart failure.There is no difference between two types of cardiomyopathies in heart failure.

关 键 词：充血性心力衰竭 心肌病 细胞因子 神经激素 

分 类 号：R542.206[医药卫生—心血管疾病] R541.602[医药卫生—内科学]