TA方案新辅助化疗对青年乳腺癌中VEGF及EGFR表达的影响  

Effects of TA Neoadjuvant Chemotherapy on Expression of VEGF and EGFR in Young Patients with Breast Cancer

作　　者：李毅[1] 张雪霞[2] 李展宇[3] 周少朋[2] 

机构地区：[1]中山大学附属第五医院乳腺外科,广东省珠海市519000 [2]中山大学附属第五医院麻醉科,广东省珠海市519000 [3]中山大学附属第五医院病理科,广东省珠海市519000

出　　处：《中华全科医学》2013年第7期1027-1029,F0003,共4页Chinese Journal of General Practice

摘　　要：目的探讨TA方案新辅助化疗对青年乳腺癌患者组织中VEGF及EGFR表达的影响。方法采用免疫组织化学法检测41例青年乳腺癌患者在新辅助化疗前后乳腺癌灶组织VEGF及EGFR的表达。结果患者经TA新辅助化疗前后VEGF阳性表达率分别为60.98%(25/41)与43.90%(18/41),P=0.122;化疗前后EGFR阳性表达率分别为48.65%(27/41)与56.76%(22/41),P=0.260,差异均无统计学意义。新辅助化疗前,VEGF青年组阳性表达率与中老年组阳性表达率分别为60.98%(25/41)和37.80%(31/51),P=0.015,差异有统计学意义;新辅助化疗后,VEGF青年组阳性表达率与中老年组阳性表达率分别为43.90%(18/41)和30.49%(25/82),P=0.141,差异无统计学意义。新辅助化疗前,EGFR青年组阳性表达率与中老年组阳性表达率分别为48.65%(27/41)和40.24%(33/82),P=0.007,差异有统计学意义;新辅助化疗后,EGFR青年组阳性表达率与中老年组阳性表达率分别为37.80%(31/51)和32.93%(27/82),P=0.027,差异有统计学意义。结论青年乳腺癌癌组织VEGF与EGFR的高表达可能与其预后不良的特点有关。TA新辅助化疗后青年组与中老年组VEGF与EGFR表达均降低,而青年组EGFR降低更明显,说明在降低乳腺癌侵袭性方面,相对于中老年乳腺癌患者,新辅助化疗可能在青年组疗效更明显。Objective To study the effects of TA neoadjuvant chemotherapy on expression of VEGF and EGFR in young pa- tients with Breast Cancer. Methods Before and after neoadjuvant chemotherapy, immunohistoehemistry method was adopted to measure the expressions of VEGF and EGFR in 41 patients with breast cancer. Results Before and after the new adjuvant chem- otherapy, the positive expression rate of VEGF were 60.98% and 37.80% respectively;before and after chemotherapy, the posi- tive expression rate of EGFR were 48.65% and 56.76% respectively, the difference had no statistical significance. Before neoad- juvant chemotherapy, VEGF youth positive expression rate and other ages of positive expression rate was 60.98% （25/41） and 37.80% （31/51 ） ,P = 0.015, the difference had statistical significance;after Neoadjuvant chemotherapy, VEGF youth positive ex- pression rate and other ages of positive expression rate was 43.90% （18/41） and 30.49% （25/82） ,P = 0. 141 ,the difference was not statistical significant. Before neoadjuvant chemotherapy, EGFR youth positive expression rate and other ages of positive expression rate was 48.65 % （ 27/41 ） and 40.24% （ 33/82 ）, P = 0.007, the difference had statistical significance ; after neoadju- vant chemotherapy, EGFR youth positive expression rate and other ages of positive expression rate was 37.80% （31/51） and 32.93% （27/82） ,P = 0.027, the difference had statistical significance. Conclusion The invasion of breast cancer in youth pa- tients may be strong, with poor prognosis and high expression VEGF and EGFR in carcinoma tissues. After TA neoadjuvant chem- otherapy ,both youth and other ages patients＇ VEGF and EGFR expression were reduced, but EQFR expression were reduced more in the youth patients. In reducing invasive breast cancer, relative to the elderly patients, new adjuvant chemotherapy may have more curative effect in the youth.

关 键 词：乳腺肿瘤 化学疗法 辅助 多药耐药相关蛋白类 

分 类 号：R737.9[医药卫生—肿瘤] R730.53[医药卫生—临床医学]