食管癌外周血miRNA的研究  

Study on plasmic miRNA of esophageal cancer

作　　者：彭学宏 陈暖[2] 李克[3] 郑邦希 

机构地区：[1]汕头潮南民生医院,广东汕头515144 [2]汕头大学第一附属医院 [3]汕头大学医学院

出　　处：《中国校医》2013年第5期353-355,共3页Chinese Journal of School Doctor

基　　金：广东省科技计划项目资助(20101096)

摘　　要：目的研究食管癌外周血miRNA表达情况。方法应用芯片技术,分析研究20例食管癌病人及20例对照者外周血miRNA表达的差异。结果 11个miRNAs在食管癌病人血液中有差异。其中8个基因上调、3个基因下调。结论检测食管癌外周血miRNA可能为食管癌早期诊断提供新的生物学指标。Objective To explore the miRNA differential expression in serum of human esophageal cancer. Methods The plasmic miRNAs of 20 human esophageal cancer patients and 20 normal persons were extracted by chip technology, and the miRNA differential expressions were analyzed. Results A total of 11 differential expressed miRNAs were different, including 8 over-expression and 3 low-expression miRNAs. Conclusions The detection of miRNAs in the serum may provide a new biological indicator for diagnosis of human esophageal cancer.

关 键 词：食管肿瘤/诊断 小分子RNA/血液 肿瘤标记 生物学/血液 

分 类 号：R735.1[医药卫生—肿瘤]