TRAF1在鼻咽癌及癌旁组织中的表达  

Expression of tumor necrosis factor receptor associated factor 1 in nasopharyngeal carcinoma and paracancerous tissues

作　　者：王承兴[1] 邓锡云[1] 李晓艳[1] 肖绘[1] 曹亚[1] 

机构地区：[1]湖南医科大学肿瘤研究所,湖南长沙410078

出　　处：《癌症》2000年第9期856-858,共3页Chinese Journal of Cancer

基　　金：本课题受国家自然科学基金杰出青年基金!(39525022);美国中华医学基金!(CMB96655);国家自然科学基金重点项目!(39830410);国家重

摘　　要：目的：研究鼻咽癌组织EB病毒LMP1与TRAF1(tumornecrosisfactorreceptorassociatedfactor1)表达的关系，以探讨LMP1可能促进TRAF1表达的作用。方法：应用LMP1和TRAF1抗体对30例鼻咽癌和12例慢性炎症鼻咽粘膜石蜡标本，以SP免疫组织化学技术检测LMP1及TRAF1的表达。结果：30例鼻咽癌中16例是LMP1阳性（53.3％），17例TRAF1阳性（56.7％）。其中16例LMP1阳性中，TRAF1表达阳性为14例（87.5％），TRAF1阴性为2例（12.5％），两者差异具有显著性(P<0.01)。30例鼻咽癌中有5例带有癌旁上皮，其中3例癌旁上皮LMP1及TRAF1均表达阳性;1例LMP1阳性，TRAF1表达阴性;1例LMP1与TRAF1均表达阴性。而12例慢性炎症鼻咽粘膜LMP1及TRAF1均无表达。结论：鼻咽癌组织中LMP1阳性者有较高的TRAF1表达，可能由于LMP1的表达促进了TRAF1表达。Objective： To investigate the relationship between EBV encoded LMP1 and TRAF1 in nasopharyngeal carcinoma as well as its significance. Method： LMP1 and TRAF1 expression in 30 cases of nasopharyngeal carcinoma tissue and cancer adjacent mucosa was detected with immunohistochemistry techniques. Results： LMP1 and TRAF1 were not expressed in chronic nasopharyngitis mucosa. In contrast， the expression rate of TRAF1 and LMP1 was 56.7％ and 53.3％ respectively, and the overexpression of TRAF1 was found in 13/16(87.5％ ) of LMP1 positive cases. Moreover， TRAF1 and LMP1 was obviously expressed in paracancerous tissues in 3 at of 5 cases， and the expression of TRAF1 was negative in the other 2 cases， in which was LMP1 positive. Conclusion： TRAF1 expression may be induced by EBV encoded LMP1 in nasopharyngeal carcinoma, which might contribute to the development of the carcinoma.

关 键 词：鼻咽肿瘤 EB病毒 TRAF1 免疫组化 癌旁组织 

分 类 号：R739.63[医药卫生—肿瘤]