AP-2γ在胃癌中表达的临床病理意义  

Expression of AP-2γ in Human Gastric Cancer and its Clinicopathologic Significance

作　　者：王玹[1,2] 张翔[2] 倪斌 朱宏辉 赵帅 苏波[2] 苏琦[2] 

机构地区：[1]长沙市第三医院,湖南长沙430100 [2]南华大学肿瘤研究所,湖南省高校肿瘤细胞与分子病理学重点实验室,湖南衡阳421001

出　　处：《中国医药指南》2013年第9期1-3,共3页Guide of China Medicine

基　　金：国家自然科学基金(31000629);湖南省卫生厅科研项目(B2008-067)

摘　　要：目的研究AP-2γ表达与胃癌发生、分化程度、肿瘤大小、淋巴结转移、临床分期的关系。方法将81例胃癌、胃黏膜癌前病变26例及正常胃黏膜组织34制成组织芯片,采用免疫组化技术检测胃癌、癌前病变及正常组织中AP-2γ表达。结果 AP-2γ表达在胃癌76.54%与癌前病变69.23%明显高于正常胃黏膜35.29%(P<0.05)。癌前病变低于胃癌(P<0.05)。高分化腺癌AP-2γ表达率40.00%明显低于中分化70.59%与低分化腺癌81.36%(P<0.05)。而低分化腺癌显著高于中分化腺癌(P<0.05)。≤3.0cm表达59.38%低于>3.0cm的87.76%(P<0.05)。淋巴结转移83.64%明显高于无转移61.54%(P<0.05)。Ⅰ+Ⅱ期表达59.38%明显低于Ⅲ+Ⅳ期87.76%(P<0.05)。结论 AP-2γ在胃癌高表达与胃癌的发生、肿瘤大小、分化程度、淋巴结转移、临床分期密切相关,其可能是胃癌侵袭转移的重要标记。Objective To investigate the clinicopathologic significance of AP-2γ expression in human gastric cancer.Methods The expression of AP2γ in gastric cancer,precancerosis and normal tissue was examined by immunohistochemistry.Results The level of expression of AP-2γ in gastric cancer was 76.54%.significantly higher than 69.23%in precancerosis and 35.29% in normal tissue（P0.05）.AP-2γ expression in well-differentiated was 40% lower than 70.21%in moderately differentiated and 96.67% in poorly differentiated adenocarcinoma,and in moderately differentiated was lower than in poorly differentiated adenocarcinoma,respectively（P0.05）.The expression of AP-2γ was 59.38% in volume≤3.0cm lower than in 3.0cm（P0.05）.The expression of AP-2γ of lymph node metastasis was 83.64%（46/55） significantly higher than 61.54%in non-lymph node metastasis（P0.05）.The expression of AP-2γ was 60.98% inⅠ＋Ⅱ stage,significantly lower than 87.76% in Ⅲ＋Ⅳ（P0.05）.Conclusions The expression of AP-2γ is closely related to carcinogenesis,tumor size,pathological classification,lymph node metastasis and clinical stage in gastric cancer,it suggest that AP-2γ may be a important biomark of invasion and metastasis.

关 键 词：胃癌 AP-2γ 组织芯片 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]