盐酸右美托咪啶预防食管癌患者麻醉苏醒期心血管反应的观察  

Observation of Dexmedetomidine Hydrochloride on Preventing Cardiovascular Response in Recovery Period after Anesthesia in Elderly Patients with Esophageal Cancer

作　　者：李英娜[1] 刘志建[2] 侴伟平[1] 黄泽清[1] 

机构地区：[1]辽宁省肿瘤医院麻醉科,沈阳市110032 [2]沈阳市儿童医院耳鼻喉科,110032

出　　处：《中华全科医学》2013年第6期848-850,共3页Chinese Journal of General Practice

摘　　要：目的对盐酸右美托咪啶预防中老年食管癌患者麻醉苏醒期的心血管反应进行观察。方法 2009年1月-2011年12月因食管癌行手术治疗的中老年患者共90例,随机分为A组(盐酸右美托咪啶组)和B组(对照组)各45例,比较两组患者麻醉后的情况。结果 B组拔管前、拔管时、拔管后5 min MAP和HR均高于A组,拔管后10 minMAP仍高于A组,差异均有统计学意义(P<0.05);A组患者镇静评分均集中在2～4分,总镇静率为100.0%,B组患者镇静评分集中在1～2分,总镇静率仅57.8%,两组比较差异有统计学意义(χ2=24.085,P=0.000);A组苏醒期躁动率仅为13.3%,B组苏醒期躁动率高达44.4%,两组比较差异有统计学意义(χ2=10.601,P=0.001)。结论 0.5μg/(kg.h)剂量盐酸右美托咪啶可有效预防中老年食管癌患者麻醉苏醒期的心血管反应。Objective To observe the effect of dexmedetomidine hydrochloride on preventing cardiovascular response in re- covery, period after anesthesia in elderly patients with esophageal cancer. Methods Total 90 elderly patients with esophageal cancer from January 2009 to December 2011 were randomly divided into group A（ dexmedetomidine hydrochloride group） and group B（ control group） ,45 cases in each group. The situation after anesthesia was compared. Results MAP and HR＇were higher in group B before extubation, at extubation,5 min after extubation than group A, 10 min after extubation, MAP was still higher in group A, there was significant （ P 〈 0.05 ） ; Sedation score in group A was concentrated in the 2 - 4 points, total sedation rate was 100.0% ,and sedation scores in group B was concentrated in the 1 -2 points,total sedation rate was only 57.8% ,there was sig- nificant（ X2 = 24.085 ,P = 0.000） ;Agitation rate in group A was only 13.3%, and agitation rate in group B was up to 44.4% , there was statistically significant（ X2 = 10.601 ,P = 0. 001 ）. Conclusion Dexmedetomidine hydrochloride at 0.5 μg/（ kg · h） dose is effective for preventing cardiovascular responses in elderly patients with esophageal anesthesia in recovery period.

关 键 词：盐酸右美托咪啶 食管癌 麻醉苏醒期 心血管反应 

分 类 号：R735.1[医药卫生—肿瘤] R614.2[医药卫生—临床医学]