结肠癌VEGF-C表达与淋巴管生成、淋巴结转移的关系  

Relationship between VEGF-C and Lymphangiogenesis,Lymph Node Metastasis in Colon Carcinoma

作　　者：张泽进 张东卫 谭莹 

机构地区：[1]广东省深圳市观澜人民医院内二科,518110

出　　处：《中华全科医学》2013年第6期867-869,共3页Chinese Journal of General Practice

摘　　要：目的探讨结肠癌血管内皮细胞生长因子-C(VEGF-C)表达与淋巴管生成、淋巴结转移的关系。方法收集深圳市观澜人民医院手术切除并经病理证实的结肠癌标本50例为研究组,包括淋巴结转移28例(转移亚组),无淋巴结转移22例(未转移亚组),另收集同期结肠良性息肉40例为对照组,对标本行VEGF-C、VEGFR-3(血管内皮细胞生长因子受体-3)免疫组化染色,分析VEGF-C表达与淋巴管密度及淋巴结转移的关系。结果研究组VEGF-C阳性率、淋巴管密度显著高于对照组(P<0.01),转移亚组VEGF-C阳性率显著高于未转移亚组(90.0%vs 31.8%,P<0.01)。结论结肠癌VEGF-C的高表达,可能通过淋巴管生成促进淋巴结转移。Objective To explore the relationship between VEGF-C and lymphangiogenesis, lymphatic metastasis in colon carcinoma. Methods Total 50 patients with colon carcinoma （Study Group） diagnosed by surgery and pathology were divided in- to lymph node metastasis subgroup（28 cases） and non-metastasis subgroup（22 cases）. 40 patients with benign colon polyp （Con- trol Group） were collected. The expression of VEGF-C and VEGFR-3 in tumor tissues was detected by immunohistochemical technology. The relationship between VEGF-C expression and LVD,lymph node metastasis was analyzed. Results Study group had significantly higher VEGF-C positive rate and LVD level as compared to Control Group（ P 〈 0.01 ）. Lymph node metastasis subgroup had a higher VEGF-C expression as compared to non- metastasis subgroup（90% vs 31.8% ,P 〈 0.01 ）. Conclusion The high expression of VEGF-C may accelerate lymphatic metastasis in colon carcinoma by lymphangiogenesis.

关 键 词：结肠癌 血管内皮细胞生长因子-C 血管内皮细胞生长因子受体-3 淋巴管生成 淋巴结转移 

分 类 号：R735.35[医药卫生—肿瘤] R730.21[医药卫生—临床医学]