双环醇预防恶性血液病患者化疗后急性药物性肝损伤的前瞻性随机对照研究  

A prospective randomized controlled study for prophylaxis of chemotherapy drug induced acute liver injury treated by bicyclol in haematological malignancy patients

作　　者：杨栋林[1] 何祎[1] 翟卫华[1] 弓晓媛[1] 石茵[1] 刘庆珍[1] 吕瑞[1] 白雪莲[1] 周卢琨[1] 庞爱明[1] 冯四洲[1] 韩明哲[1] 

机构地区：[1]中国医学科学院北京协和医学院血液学研究所血液病医院干细胞移植中心,天津300020

出　　处：《胃肠病学和肝病学杂志》2013年第5期461-465,共5页Chinese Journal of Gastroenterology and Hepatology

基　　金：天津市自然基金(10JCYBJC13100;09JCYBJC11000);卫生部卫生行业科研专项(201202017)

摘　　要：目的观察双环醇预防恶性血液病患者化疗后急性药物性肝损伤的效果。方法采用前瞻性随机对照研究,双环醇预防组为治疗组,腺苷蛋氨酸预防组为对照组。结果共219例次化疗,可评价疗效的213例次化疗患者,预防失败率16.9%。治疗组预防失败率为10.3%,明显低于对照组的24.7%,两组比较差异具有显著统计学意义(P<0.01)。对照组有6例患者因药物不良反应而停药,治疗组无患者因不良反应停药(P<0.05)。结论双环醇是预防恶性血液病患者化疗后急性药物性肝损伤的有效、安全药物。Objective To evaluate prophylactic effect of bicyelol and ademetionine tablets on chemotherapy drug in- duced acute liver injury in haematological malignancy patients. Methods A prospective randomized controlled trial was conducted in 219 cases of haematologieal malignancy for evaluating prophylactic efficacy on chemotherapy drug induced acute liver injury. Patients were randomly divided into bicyclol tablets therapy group and ademetionine control group. Results Acute liver injury developed in the 16.9% cases of all evaluable 213 patients. The failure rate was 10.3% and 24.7% in therapy group and control group, respectively. The difference was statistically significant between the two groups （P 〈0.01 ）. There were 6 cases ceasing the drug due to intolerance in control group, and no case withdrew in therapy group （P 〈 0.05）. Conclusion Bicyclol tablets therapy appears to be a safe and effective prophylaxis regimen for alleviation of chemotherapy drug induced acute liver injury in haematological malignancy patients.

关 键 词：双环醇 腺苷蛋氨酸 药物性肝损伤 化疗 血液病 

分 类 号：R575.1[医药卫生—消化系统]