In vitro Study on Biodegradable AZ31 Magnesium Alloy Fibers Reinforced PLGA Composite  

作　　者：Y.H.Wu N.Li Y.Cheng Y.F.Zheng Y.Han 

机构地区：[1]Center for Biomedical Materials and Tissue Engineering,Academy for Advanced Interdisciplinary Studies,Peking University [2]Department of Materials Science and Engineering,College of Engineering,Peking University [3]State Key Laboratory for Mechanical Behavior of Materials,Xi'an Jiaotong University

出　　处：《Journal of Materials Science & Technology》2013年第6期545-550,共6页材料科学技术（英文版）

基　　金：supported by the National Basic Research Program of China(973 Program)(Grant Nos.2012CB619102 and 2012CB619103);the State Key Laboratory for Mechanical Behavior of Materials(Grant No.20111210);the National High Technology Research and Development Program of China(863 Program)(Grant No.2011AA030103);the Research Fund for the Doctoral Program of Higher Education(Grant No. 20100001110011);the National Natural Science Foundation of China(No.31170909);the National Science Fund for Distinguished Young Scholars(Grant No.51225101)

摘　　要：AZ31 magnesium alloy fibers reinforced poly（lactic-co-glycolic acid） （PLGA） composites were prepared and their mechanical property, immersion corrosion behavior and biocompatibility were studied. The tensile test showed that with the addition of AZ31 fibers, the composites had a significant increment in tensile strength and elongation. For the direct cell attachment test, all the cells showed a healthy morphology and spread well on the experimental sample surfaces. The immersion results indicated that pH values of the immersion medium increased with increasing AZ31 fiber contents. All the in vitro experimental results indicated that this new kind of magnesium alloy fibers reinforced PLGA composites show a potential for future biomedical applications.AZ31 magnesium alloy fibers reinforced poly（lactic-co-glycolic acid） （PLGA） composites were prepared and their mechanical property, immersion corrosion behavior and biocompatibility were studied. The tensile test showed that with the addition of AZ31 fibers, the composites had a significant increment in tensile strength and elongation. For the direct cell attachment test, all the cells showed a healthy morphology and spread well on the experimental sample surfaces. The immersion results indicated that pH values of the immersion medium increased with increasing AZ31 fiber contents. All the in vitro experimental results indicated that this new kind of magnesium alloy fibers reinforced PLGA composites show a potential for future biomedical applications.

关 键 词：BIOMATERIALS Corrosion Polymeric composites AZ31 magnesium fiber 

分 类 号：R318.08[医药卫生—生物医学工程]